2-(diethylamino)-N-mesitylacetamide hydrochloride 盐酸三甲卡因

CAS 1027-14-1 MFCD01027141

化学结构图

1027-14-1
SMILES: CCN(CC)CC(=O)Nc1c(C)cc(C)cc1C.Cl

化学属性

Mol. Weight284.87
Mol. FormulaC15H24N2O.ClH

别名和识别编码

CAS Number1027-14-1
Chemical Name2-(diethylamino)-N-mesitylacetamide hydrochloride
Synonym 2-Diethylamino-2',4',6'-trimethylacetanilide hydrochloride Diethylaminoacetyl 2,4,6-trimethyl-aniline hydrochloride Mesocain 2-(Diethylamino)-2',4',6'-trimethylacetanilide Monohydrochloride Mesocaine Trimecaine hydrochloride Mesokain 2-(Diethylamino)-N-(2,4,6-trimethylphenyl)acetamide Hydrochloride Mesidicaine hydrochloride N-sym-Trimethylphenyldiethylaminoacetamide hydrochloride Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl-, monohydrochloride Trimekain hydrochloride Trimekain Hydrochloride Acetamide, 2-(diethylamino)-N-(2,4,6-trimethylphenyl)-, monohydrochloride
Chemical Name Translation盐酸三甲卡因
Wiswesser Line Notation2N2&1VMR B1 D1 F1 &GH
LabNetwork Molecule IDLN00437556
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A local anesthetic and cardial antiarrhythmic. It used in epidural postoperative analgesia after major urological procedures in combination with morphine.

相关文献及参考

  • Dostalova, V. et al.: Bratisl. Lek. Listy, 109, 11 (2008); Gendenshtein, E.I. et al.: Kardiol., 16, 128 (1976); Stolc, S. et al.: Eur. J. Pharmacol., 164, 249 (1989);

安全信息

RTECSAE2100000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 25,731,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 295 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,1526,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 172 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFPCAG Acta Facultatis Pharmaceuticae, Universitatis Comenianae.  (Ustredna
   Kniznica Farmaceuticka Fakulta Univerzity Komenskeho, Sasinkova 5, 886 34
   Bratislava, Czechoslovakia)  V.14-    1967-  Volume(issue)/page/year:
   29,81,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMDIEQ Drug Metabolism and Drug Interactions.  (Freund Publishing House,
   Suite 500, Chesham House, 150 Regent Street, London, W1R 5FA, United
   Kingd

系列性分类

相关产品推荐