(2S,2’S)-2,2’-(Ethane-1,2-Diylbis(Azanediyl))Bis(Butan-1-Ol) Dihydrochloride (S,S)-N,N’-双(1-羟基-2-丁基)乙二胺二盐酸盐
CAS 1070-11-7 MFCD00216025
化学结构图
SMILES: CC[C@H](CO)NCCN[C@H](CC)CO.Cl.Cl
化学属性
| Mol. Formula | C10H24N2O2.2HCl |
|---|---|
| Mol. Weight | 277.23 |
| Melting Point | 199.0 to 204.0 deg-C |
| TSCA | No |
| Solubility | DMSO 56 mg/mL Water 56 mg/mL Ethanol <1 mg/mL |
别名和识别编码
| Chemical Name | (2S,2’S)-2,2’-(Ethane-1,2-Diylbis(Azanediyl))Bis(Butan-1-Ol) Dihydrochloride |
|---|---|
| CAS Number | 1070-11-7 |
| Synonym | 2,2’-(1,2-ethanediyldiimino)bis-,dihydrochloride,(r-(r*,r*))-1-butano ETHAMBUTOL HCL Myambutol 1-Butanol, 2,2'-(ethylenediimino)di-, dihydrochloride, (+)- (8CI) (S,S)-2,2?-(1,2-Ethanediyldiimino)-bis-1-butanol Dihydrochloride 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; [S-(R*,R*)]-2,2'-(Ethylenediimino)dibutan-1-ol dihydrochloride Tibutol 2,2'-(1,2-ETHANEDIYLDIIMINO)BIS-1-BUTANOL DIHYDROCHLORIDE ETHAMBUTOL DIHYDROCHLORIDE EMB DIHYDROCHLORIDE 乙胺丁醇二盐酸盐 盐酸乙胺丁醇; 乙胺丁醇二盐酸盐; 2,2'-(1,2-乙二胺)二-1-丁醇二盐酸盐;(S,S)-2,2'-(1,2-乙二基二亚氨基)双-1-丁醇二盐酸盐;(S,S)-N,N'-双(1-羟基-2-丁基)乙二胺二盐酸盐 EMB Etibi Dexambutol ETHAMBUTOL HYDROCHLORIDE [s-(r*,r*)]-2,2'-(ethylenediimino)dibutan-1-ol dihydrochloride Sural 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, [S-(R*,R*)]- 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, ETHAMBUTOL 2HCL 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, hydrochloride (1?), (2S,2'S)- Ethambutol dihydrochloride 2,2’-(ethylenediimino)di-,dihydrochloride,(+)-1-butano 盐酸乙胺丁醇 d-2,2'-(Ethylenediimino)-di-1-butanol dihydrochloride 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride Mycobutol cl40881 Etapiam (+)-2,2'-(Ethylenediimino)di-1-butanol dihydrochloride Ebutol dadibutol 2,2'-(1,2-乙二胺)二-1-丁醇二盐酸盐 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride Emb EthambutolHclEthambutolHclBp 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, (2S,2'S)- |
| MDL Number | MFCD00216025 |
| PubChem Substance ID | 14051 |
| EC Number | 213-970-7 |
| Merck Number | 3720 |
| Chemical Name Translation | (S,S)-N,N’-双(1-羟基-2-丁基)乙二胺二盐酸盐 |
| Wiswesser Line Notation | Q1Y2&M2MY2&1Q &GH 2 |
| InChI | InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1 |
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分类
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
- {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antimycobacterial, Interferes with Cell Wall Synthesis, Mechanism of Action, Spectrum of Activity
产品应用
- A tuberculostatic antibacterial.
相关文献及参考
- Wilkinson, et al.: J. Med. Chem., 5, 835 (1962),
- Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971),
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 45 mg/kg/3D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - effect, not otherwise specified REFERENCE : BJDCAT British Journal of Diseases of the Chest. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.53- 1959- Volume(issue)/page/year: 80,288,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,70,1968
TY
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OB
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 50 mg/kg REFERENCE : IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year: 10,135,1982
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 12500 ug/kg REFERENCE : IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year: 10,135,1982
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 4400 mg/L REFERENCE : IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ. Volume(issue)/page/year: 14,745,1986
其他信息
- Sigma Aldrich:1070-11-7(sigmaaldrich)
- MOL 文件:1070-11-7.mol
- Ethambutol dihydrochloride
- Ethambutol HCl是一种抗分枝杆菌抑菌剂, 通过抑制阿拉伯糖基转移酶来干扰细胞壁形成。
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