Meclizine Dihydrochloride 盐酸美克洛嗪

CAS 1104-22-9 MFCD00058199

化学结构图

1104-22-9
SMILES: Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl.Cl

化学属性

Mol. FormulaC25ClH27N2·2HCl
Mol. Weight464
SolubilitySoluble in Chloroform and DMSO
Melting Point210-214

别名和识别编码

Chemical NameMeclizine Dihydrochloride
CAS Number1104-22-9
Alfabeta NameCHLOROPHENYLPHENYLMETHYLMETHYLBENZYLPIPERAZINEDIHYDROCHLORIDE 1443(((())))-----
MDL NumberMFCD00058199
Synonym 1-(p-Chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride Meclizine diHCl Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, NSC 28728 parachloraminedihydrochloride Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (9CI) bonamine Ancolan dihydrochloride Piperazine, 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride (6CI, 8CI) 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-piperazindih Diadril meclozinedihydrochloride Postafene dihydrochloride Parachloramine dihydrochloride 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-piperazindihyd Meclozine dihydrochloride monohydrate 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-piperazindihydrochlorid mecilizine hydrochloride Navidoxine MECLIZINE DIHYDROCHLORIDE Bonamine 1-([4-Chlorophenyl]phenylmethyl)-4-([3-methylphenyl]methyl)piperazine Meclizine dihydrochloride diadril 1-p-Chlorbenzhydryl-m-methylbenzylpiperazine dihydrochloride ancolandihydrochloride 1-p-chlorbenzhydryl-m-methylbenzylpiperazinedihydrochloride 盐酸美克洛嗪; 盐酸氯苯苄嗪; 1-((4-氯苯基)苯甲基)-4-((3-甲苯基)甲基)哌嗪二盐酸盐 1-([4-CHLOROPHENYL]PHENYLMETHYL)-4-([3-METHYLPHENYL]-METHYL)PIPERAZINE DIHYDROCHLORIDE Meclozine dihydrochloride 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride 盐酸氯苯苄嗪 1-((4-氯苯基)苯甲基)-4-((3-甲苯基)甲基)哌嗪二盐酸盐 盐酸美克洛嗪
EC Number214-164-8
Chemical Name Translation盐酸美克洛嗪
Wiswesser Line NotationT6N DNTJ AYR&R DG& D1R C1 &GH 2
Beilstein Registry Number3798111
LabNetwork Molecule IDLN00174195
Reaxys-RN3798111
PubChem Substance ID253661196
InChIInChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
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产品应用

  • A histamine H1 receptor antagonist and pregnane X receptor (PXR) agonist

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P308+P313
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
RTECSTL2005000
Signal word Warning
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 5.1
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Storage condition 0-10°C 2-8°C 储存温度 2-8°C 储存温度-20°C
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,67,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 625 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory obstruction
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,653,1954

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   MPHEAE Medicina et Pharmacologia Experimentalis.  (Basel, Switzerland)
   V.12-17, 1965-67.  For publisher information, see PHMGBN.
   Volume(issue)/page/year: 15,375,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   MPHEAE Medicina et Pharmacologia Experimentalis.  (Basel, Switzerland)
   V.12-17, 1965-67.  For publisher information, see PHMGBN.
   Volume(issue)/page/year: 15,375,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - homeostasis
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   MPHEAE Medicina et Pharmacologia Experimentalis.  (Basel, Switzerland)
   V.12-17, 1965-67.  For publisher information, see PHMGBN.
   Volume(issue)/page/year: 15,375,1966

UN Number 3099
Packing GroupIII

其他信息

  • MOL 文件:1104-22-9.mol
  • Meclozine dihydrochloride
  • Meclizine 2HCl 是histamine H1 receptor拮抗剂,用于治疗恶心,晕动病,也是mCAR(组成型雄烷受体激动剂配体)激动剂配体,也是hCAR的反向激动剂。

系列性分类


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