Isotibolone

CAS 1162-60-3 MFCD N/A

化学结构图

1162-60-3
SMILES: C#C[C@]1(O)CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@H]1CCC(=O)C=C1C[C@H]3C

化学属性

Mol. Weight312.49
Mol. FormulaC21H28O2

别名和识别编码

CAS Number1162-60-3
Chemical NameIsotibolone
Synonym 17?-Ethynyl-17 U-13,851 7-alpha-Methyl-17-ethinyl-19-nortestosterone (7?,17?)-17-Hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one
InChIKeyWAOKMNBZWBGYIK-KIURNNQRSA-N
Chemical Name Translation
Wiswesser Line NotationL E5 B666 OV MUTJ E1 FQ F1UU1 K1
Beilstein Registry Number4263193
PubChem Substance ID22814761
InChIInChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,12-13,16-19,23H,5-11H2,2-3H3/t13-,16+,17-,18+,19-,20+,21+/m1/s1
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分类

  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids,

产品应用

  • A metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.

相关文献及参考

  • Clarkson, T., et al.: J. Clin. Endocrinol. Metab., 86, 5396 (2001),

安全信息

RTECSRC9027000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 1,87,1970

系列性分类

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