(S)-2-Ureidopentanedioic Acid N-氨基甲酰基-L-谷氨酸

CAS 1188-38-1 MFCD00047874

化学结构图

1188-38-1
SMILES: NC(=O)N[C@@H](CCC(=O)O)C(=O)O

化学属性

Mol. FormulaC6H10N2O5
Mol. Weight190

别名和识别编码

Chemical Name(S)-2-Ureidopentanedioic Acid
CAS Number1188-38-1
Synonym Carbaglu Carbamino-L-glutamic Acid Carbamino-L-glutamic acid Carbamylglutamic Acid Carbamylglutamic acid Carglumic Acid Glutamic acid, N-carbamoyl-, L- N-(Aminoc N-Carbamoyl-L-glutamic Acid N-Carbamoyl-S-glutamic Acid N-Carbamyl-L-glutamic Acid N-Carbamyl-L-glutamic acid N-氨基甲酰-L-谷氨酸 OE 312 Ureidoglutaric Acid Ureidoglutaric acid
MDL NumberMFCD00047874
PubChem Substance ID121396
Chemical Name TranslationN-氨基甲酰基-L-谷氨酸
InChIInChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
LabNetwork Molecule IDLN01262803
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分类

  • Amino Acids & Derivatives
  • Pharmaceuticals
  • {SNA} A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids
  • Intermediates & Fine Chemicals
  • {SNA} A - H, Amino Acids, Modified Amino Acids, 生化试剂

产品应用

  • N-Carbamyl-L-glutamic Acid has been shown to have protective effects against ammonia intoxication and is used in the treatment of acute hyperammonemia.

相关文献及参考

  • Paik, W.K. et al.: Life Sci., 15, 1189 (1974); O'Connor, J.E. et al.: Eur. J. Pediat., 148, 540 (1989); Lee, J.H. et al.: Biochem. Biophys. Res. Chem., 248, 391 (1998);

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSLZ9870000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 24(4),32,1990

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Modified Amino Acids - Amino Acids
  5. A - H - Modified Amino Acids

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