2-Amino-5-Nitrothiazole 2-氨基-5-硝基噻唑

CAS 121-66-4 MFCD00005326

化学结构图

121-66-4
SMILES: Nc1ncc([N+](=O)[O-])s1

化学属性

Mol. FormulaC3H3N3O2S
Mol. Weight145
Melting Point195-200 °C (dec.)(lit.)
TSCAYes
Solubility<0.1 G/100 ML AT 20 ºC
Appearance 黄色晶体。微苦。 溶于热水及稀酸,微溶于水及有机溶剂(如乙醇、乙醚)。

别名和识别编码

Chemical Name2-Amino-5-Nitrothiazole
CAS Number121-66-4
Alfabeta NameNITROTHIAZOLAMINE 52---
Synonym 2-Thiazolamine, 5-nitro- aminzolsoluble ENHEPTYNE ENHEPTIN 2-氨基-5-硝基噻唑 硝胺噻唑 2-AMINO-5-NITRO-1,3-THIAZOLE 2-AMINO-5-NITROTHIAZOLE AKOS BBS-00006479 5-Nitro-2-thiazolamine aminonitrothiazolum USAF EK-6561 Enheptin T 5-NITRO-1,3-THIAZOL-2-AMINE AURORA KA-644 Aminonitrothiazole ENTRAMINE 2-Amino-5-nitrothiazole 2-Amino-5-nitro-1,3-thiazole 5-nitro-2-thiazolylamine 胺硝噻唑 醋硝噻唑 aminonitrothiazole 5-Nitro-2-aminothiazole 5-Nitro-2-thiazolylamine NCI-C03065 5-nitro-2-thiazolamin amnizolsoluble NSC 4 2-amino-5-nitro-thiazol 5-硝基-2-噻唑胺 Aminzol soluble 5-Nitro-2-aminothiazole; Enheptyne Enheptin-T Aminonitrothiazolum 2-AMINO-5-NITRO-THIAZOLE HYDROCHLORIDE AKOS 203 2-氨基-5-硝基噻唑 2-AMINO-5-NITROTHIAZOLE 氨硝噻唑 5-nitro-2-aminothiazole Entramin Enheptin Nitramin IDO 乙酰胺硝噻唑 5-nitro-2-Thiazolamine LABOTEST-BB LT00129612 Enheptin premix
MDL NumberMFCD00005326
PubChem Substance ID8486
Beilstein Registry Number126797
EC Number204-490-9
Merck Number457
Reaxys-RN126797
Chemical Name Translation2-氨基-5-硝基噻唑
Wiswesser Line NotationT5N CSJ BZ DNW
LabNetwork Molecule IDLN00174857
InChIInChI=1S/C3H3N3O2S/c4-3-5-1-2(9-3)6(7)8/h1H,(H2,4,5)
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分类

  • Amine
  • Miscellaneous Reagents
  • {SNA} Building Blocks, C3 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Thiazoles

相关文献及参考

  • Kariduraganavar, M. et al.; J. Mol. Struct. 987, 158 (2011). Tambe, S. J. et al.; Appl Polymer Sci. 114, 2291 (2009)

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P332+P313
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSXJ2800000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
Hazard Codes Xn Xn,Xi
UN Number 2811
Storage condition Light Sensitive
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-53,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 gm/kg/46W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,841,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-53,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 14500 ng/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 200 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 118,153,1983

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,359,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 74 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12(Suppl 13),37,1988

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,81,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   WTMOA3 Wiener Tieraerztliche Monatsschrift.  (Ferdinand Berger & Soehne OHG,
   Wiene Str. 21-23, A-3580 Horn, Austria)  V.1-    1914-
   Volume(issue)/page/year: 69,19,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,418,1960

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,418,1960

其他信息

  • Acros Organics:2-氨基-5-硝基噻唑 2-Amino-5-nitrothiazole, 97%(121-66-4)
  • 上游原料:硫酸 --> 硫脲 --> 2-氨基噻唑
  • MOL 文件:121-66-4.mol
  • Alfa Aesar:2-氨基-5-硝基噻唑,97% 2-Amino-5-nitrothiazole, 97%(121-66-4)
  • TCI Shanghai:2-氨基-5-硝基噻唑 2-Amino-5-nitrothiazole,>;98.0%(LC)(T)(121-66-4)
  • F:8
  • 灭火剂:干粉、泡沫、砂土, 二氧化碳, 雾状水
  • 毒性分级:高毒
  • 急性毒性:腹腔-小鼠LD50: 200 毫克/公斤
  • 储运特性:库房通风低温干燥; 与硫酸和硝酸分开存放
  • Hazard Note:Irritant
  • Sigma Aldrich:121-66-4(sigmaaldrich)
  • MSDS 信息:2-Amino-5-nitrothiazole(121-66-4).msds
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
  • 图谱信息:2-氨基-5-硝基噻唑(121-66-4)红外图谱(IR2) 2-氨基-5-硝基噻唑(121-66-4)红外图谱(IR1) 2-氨基-5-硝基噻唑(121-66-4)质谱(MS)
  • 2-氨基-5-硝基噻唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0381 2-氨基-5-硝基噻唑 2-Amino-5-nitrothiazole 500G 2660元 2014/06/02 A0381 2-氨基-5-硝基噻唑 2-Amino-5-nitrothiazole 25G 325元 2010/06/21 158520250 2-氨基-5-硝基噻唑 2-Amino-5-nitrothiazole 97% 25 GR 317元
  • 下游产品:2-溴-5-硝基噻唑 --> 分散蓝102号滤饼 --> 分散兰284
  • 用途一:用作制备偶氮杂环染料的重要中间体
  • 类别:有毒物品

系列性分类


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