(+)-Griseofulvin (+)-灰黄霉素
CAS 126-07-8 MFCD00082343
化学结构图
SMILES: COC1=CC(=O)CC(C)C12Oc1c(Cl)c(OC)cc(OC)c1C2=O
化学属性
| Mol. Formula | C17H17ClO6 |
|---|---|
| Mol. Weight | 353 |
| Melting Point | 218-222 |
| TSCA | No |
| Solubility | 难溶 |
| Density | 1.38 |
| Boiling Point | 570.4 |
别名和识别编码
| Chemical Name | (+)-Griseofulvin |
|---|---|
| Synonym | (+)-griseofulvi (+)-灰黄霉素 (+)-灰黄霉素,97% (2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE (2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione (2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy 2’-en-4’-one) 6'-甲基-2' 6-dimethoxycoumaran-3-one-2-spiro-1’-(2’-methoxy-6’-me 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione Curling factor Fulcine Fulvicin Fulvicin-P/G Fulvina Gresfeed Grifulvin V Grisefuline Griseofulvin Griseofulvin-fort Guservin Sporostatin clohexene]-3,4’-dione 灰黄霉素 |
| MDL Number | MFCD00082343 |
| PubChem Substance ID | 135727206 |
| Beilstein Registry Number | 95226 |
| CAS Number | 126-07-8 |
| EC Number | 204-767-4 |
| Reaxys-RN | 95226 |
| Merck Number | 4549 |
| Chemical Name Translation | (+)-灰黄霉素 |
| Wiswesser Line Notation | T56 BOXVJ FO1 HO1 IG C-& DL6V DX BUTJ CO1 E1 |
| LabNetwork Molecule ID | LN00839705 |
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分类
- {SNA} Alphabetical Index of Analytical
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal, Biochemicals and Reagents, Chemical Structure, Chromatography, Clinical Standards, Environmental Standards, Fungicides, G, Others, Pesticides, Pesticides & Metabolites, Spectrum of Activity
- {SNA} Analytical Standards, Analytical
- {SNA} Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal, Biochemicals and Reagents, Spectrum of Activity
产品应用
- An antifungal and antiproliferative agent that affects microtubules.
相关文献及参考
- Merck: 14,4549
- Merck: 14,4549 Beilstein: 18,V,5,150
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P308 IF exposed or concerned: 如果接触或涉及
- P308+P311
- P308+P313
- P313 Get medical advice/attention. 获取医疗咨询/就医
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H340 May cause genetic defects 可能导致遗传性缺陷
- H351 Suspected of causing cancer 怀疑致癌
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R60 May impair fertility 可能降低生殖能力
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 440 gm/kg/52W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,721,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg/49W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 27,1900,1967
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 462 gm/kg/2Y-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Blood - lymphoma, including Hodgkin's disease REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 38,237,1978
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 730 gm/kg/52W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,721,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,44,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Blood - changes in cell count (unspecified) Blood - changes in bone marrow (not otherwise specified) REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 182,1320,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >50 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,44,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 2 gm/L REFERENCE : GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965- Volume(issue)/page/year: 30(6),796,1994
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 5 mg/L REFERENCE : MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,165,1989
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 6 mg/L REFERENCE : JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 8 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/yea
TYPE OF TEST : Mutation test systems - not otherw
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 50 mg/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 253,361,1975
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Embryo DOSE/DURATION : 50 mg/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/y
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 500 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 14,44,1969
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DO
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 10 gm/kg SEX/DURATION : female 8-9 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : 40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,161,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 12500 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue
其他信息
- 毒性分级:低毒
- MSDS 信息:(+)-Griseofulvin(126-07-8).msds
- 易溶于四氯乙烷，溶于丙酮或氯仿，微溶于甲醇或乙醇，极微溶于水。无臭或几乎无臭，味微苦，对热稳定。
- 灭火剂:干粉、泡沫、砂土
- Alfa Aesar:(+)-灰黄霉素,97% (+)-Griseofulvin, 97%(126-07-8)
- 上游原料:淀粉 --> 草酸
- 用途三:灰黄霉素【126-07-8】为抗浅表真菌抗生素，对各种皮肤癣菌有较强的抑制任用，能干扰真菌细胞DNA的合成，抑制其生长。主要用于治疗头癣、体癣、股癣、甲癣及迭瓦癣等体表真菌感染。
- (+)-灰黄霉素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 227451000 (+)-灰黄霉素 (+)-Griseofulvin 97% 100 GR 6404元 2010/06/21 227450050 (+)-灰黄霉素 (+)-Griseofulvin 97% 5 GR 612元 2010/05/25 B23521 (+)-灰黄霉素,97% (+)-Griseofulvin, 97% 25g 1201元
- Sigma Aldrich:126-07-8(sigmaaldrich)
- 急性毒性:口服- 大鼠 LD50: 10000 毫克/ 公斤; 口服- 小鼠 LD50: 50000 毫克/ 公斤
- 方法一:灰黄霉素是自灰黄青霉菌（Penicilli-um griseofulvum）的培养发酵液中提取制得的抗生素。
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- MOL 文件:126-07-8.mol
- 类别:农药
- 贮藏:密闭，通风干燥处贮藏。
- 比旋光度:354 ° (c=1, dimethylform)
- 可燃性危险特性:燃烧产生有毒氯化物气体
- 参考量标准:符合《中国药典》2000版，《美国药典》28版，《 欧洲药典》EP5版，《英国药典》BP2003版
- Acros Organics:灰黄霉素 (+)-Griseofulvin, 97%(126-07-8)
- 图谱信息:(+)-灰黄霉素(126-07-8)红外图谱(IR1) (+)-灰黄霉素(126-07-8)红外图谱(IR2) (+)-灰黄霉素(126-07-8)核磁图( 13 CNMR)
- 用途一:对各种皮肤癣菌有抑制作用，对生长旺盛的真菌有效
- 用途二:本品对各种皮肤癣菌有抑制作用，包括皮表癣菌属、皮癣菌属和小孢子菌属。对花斑癣菌、白色含珠菌和细菌无效。本品起抑菌作用，对生长旺盛的真菌有效。本品用于敏感真菌引起的头癣、甲癣、迭瓦癣、物足癣和体癣。
- 外观:白色或类白色的微细粉末,无臭,味微苦。
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