Oxethazaine 奥昔卡因

CAS 126-27-2 MFCD00079202

化学结构图

126-27-2
SMILES: CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc1ccccc1

化学属性

Mol. FormulaC28H41N3O3
Mol. Weight468
Melting Point104-105 ºC
Solubility<0.1 G/100 ML AT 23 ºC

别名和识别编码

Chemical NameOxethazaine
CAS Number126-27-2
Synonym Oxaine 2-双(N-甲基-N-苯基叔丁基-氨基甲酰甲基)氨基乙醇 2-di(n-methyl-n-phenyl-tert-butyl-carbamoylmethyl)aminoethanol Oxetacaine OXETHAZINE mutesa 2-HYDROXYETHYLIMINOBIS-[N-(ALPHA,ALPHA-DIMETHYLPHENETHYL)-N-METHYLACETAMIDE] n,n-bis(n-methyl-n-phenyl-tert-butylacetamido)-beta-hydroxyethylamine Mucoxin Acetamide, fh099 2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol mucaine oxethacaina oxaine 羟乙卡因 oxethacaine 奥西卡因 stomacain mucoxin betalgil 2,2’-((2-hydroxyethyl)imino)bis(n-(alpha,alpha-dimethylphenethyl)-n-methylac 2,2’-((2-hydroxyethyl)imino)bis(n-(1,1-dimethyl-2-phenylethyl)-n-methylaceta OXETACAINE 阿塞赛因 Storocain 2,2’-((2-hydroxyethyl)imino)bis(n-(alpha,alpha-dimethylphenethyl)-n-acetamid acetamide,2,2’-(2-hydroxyethyl)imino)bis(n-(1,1-dimethylphenylethyl)-n-methy muthesa Betalgil FH 099 OXETHAZAINE 2,2'-[(2-Hydroxyethyl)imino]bis[N-(?,?-dimethylphenethyl)-N-methylacetamide] 奥昔卡因
MDL NumberMFCD00079202
PubChem Substance ID24898016
EC Number204-780-5
Chemical Name Translation奥昔卡因
Wiswesser Line NotationR1X1&1&N1&V1N2Q1VN1&X1&1&1R
Beilstein Registry Number2404063
LabNetwork Molecule IDLN01301069
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, O

产品应用

  • A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis.

相关文献及参考

  • Detrain, M. et al.: Acta. Gastro-Enterol. Belg., 28, 360 (1965); Barbezat, G.O. et al.: Scand. J. Gastroenterol., 13, 321 (1978); Masuda, Y. et al.: Biochem. Pharmacol., 64, 677 (2002);

安全信息

RTECSAC3325000
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 134,642,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 134,642,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,283,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GMITAB Gazzetta Medica Italiana.  (Turin, Italy)  V.95-142, 1936-83.
   Volume(issue)/page/year: 134,642,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Toky

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,159,1974

其他信息

  • MSDS 信息:2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol(126-27-2).msds
  • Sigma Aldrich:126-27-2(sigmaaldrich)
  • MOL 文件:126-27-2.mol

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. O - Alphabetic
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs &amp; Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs &amp; Metabolites

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