Colistin Sulfate Salt 硫酸粘杆菌素

CAS 1264-72-8 MFCD00146495

化学结构图

1264-72-8
SMILES: CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O.O=S(=O)(O)O

化学属性

Mol. Weight1066.51
Mol. FormulaC45H85N13O10.H2O4S
Melting Point>230
TSCANo
Appearance 硫酸粘杆菌素(1264-72-8)为白色或近白色粉末，无臭、味苦有引湿性，易溶于水，微溶于甲醇、乙醇，溶于丙酮、乙醚等，游离碱微溶于水。

别名和识别编码

CAS Number1264-72-8
Chemical NameColistin Sulfate Salt
Synonym Belcomycin COLISTIN SULFATE COLISTIN SULFATE SALT COLISTIN SULPHATE COLISTINE SULFATE COLISTINSULFATE,POWDER,USP Colistin sulfat Colistin sulfate Colistin sulfate salt 硫酸盐 Colistin sulphate premix 10% Colistin sulphate premix 10% 40% Colistin, sulfate (salt) ColistinSulfateEp5 Colomyci Colomycin Colomycin syrup POLYMYXIN E Polymyxin E sulfate (salt) Polymyxin e. sulfate; Belcomycine; Colomycin Polymyxin E belcomycin colimycinsulfate colistinsulfat colomycinsyrup {} {} {Chembli 多粘菌素 硫酸多粘霉素E 硫酸粘杆菌素 硫酸粘杆霉素 硫酸粘菌素 硫酸黏素菌 黏菌素硫酸盐
MDL NumberMFCD00146495
EC Number215-034-3
Merck Number2479
Chemical Name Translation硫酸粘杆菌素
InChIKeyZJIWRHLZXQPFAD-LRYSGCCDSA-N
PubChem Substance ID253660429
LabNetwork Molecule IDLN02127191
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分类

  • Pharmaceuticals
  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Core Bioreagents, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, Peptides, Research Essentials, Spectrum of Activity, 抗生素, 生化试剂
  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Core Bioreagents, Interferes with Cell Membrane Permeability (Ionophores), Mechanism of Action, Peptides, Research Essentials,

产品应用

  • 抗生素类药，本品由多粘杆菌产生，对革兰氏阴性菌有较强的抗菌作用，用于治疗革兰氏阴性菌引起的肠道疾病。
  • 硫酸粘杆菌素用于，穿透细菌的细胞膜和甘露糖抗血凝及某些生物的抗生素耐药性研究，如鲍曼。它也被用于研究在大鼠肾脏的hephrotoxicity，对铜绿假单胞菌的MIC值，时间杀动力学，和抗生素后效应（PAE）

相关文献及参考

  • Suzuki, T., et al.: J. Biochem., 54, 25 (1963),
  • Barnett, M., et al.: Br. J. Pharmacol. Chemother., 23, 552 (1964),
  • Littlewood, J, M., et al.: Respir. Med., 94, 632 (2000),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301 IF SWALLOWED: 如果吞下去
  • P301+P310
  • P301+P310+P330
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
RTECSTR1500000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes 6.1 T
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
UN Number 2811 UN 2811 6.1/PG 3
Packing GroupIII
Hazard Class6.1
Storage condition 储存温度2-8℃ 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,395,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72200 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 13,7,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABANAE Antibiotics Annual.  (New York, NY)  1953-60.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: 7,41,1959/1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 58 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   16,105,1968

其他信息

  • 用途一:属抗生素类药，用于治疗革兰阴性杆菌引起的肠道疾病，并有一定促生长作用
  • 用途二:抗生素类药，本品由多粘杆菌产生，对革兰氏阴性菌有较强的抗菌作用，用于治疗革兰氏阴性菌引起的肠道疾病，用作饲料添加剂，且有明显促生长作用。用法与用量：混饲。每1吨饲料添加，猪2-40g（2月龄以下）、2-20g（4月龄以下),鸡2-20g，以上均以有效成分计。
  • Sigma Aldrich:1264-72-8(sigmaaldrich)
  • 无臭、味苦有引湿性，易溶于水，微溶于甲醇、乙醇、溶于丙酮、乙醚等，游离碱微溶于水。
  • 下游产品:硫酸多黏菌素E --> 抗敌素
  • MOL 文件:1264-72-8.mol

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antibacterial - Spectrum of Activity
  5. A - K - Antibacterial

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