Cefalotin 头孢噻吩

CAS 153-61-7 MFCD00242614

化学结构图

153-61-7
SMILES: CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3cccs3)[C@H]2SC1

化学属性

Mol. FormulaC16H16N2O6S2
Mol. Weight396.44
Melting Point160-161°C
Solubility158 MG/L
Boiling Point757.2°C at 760 mmHg

别名和识别编码

Chemical NameCefalotin
CAS Number153-61-7
Alfabeta NameACETOXYMETHYLOXOTHIOPHENYLACETAMIDOTHIAAZABICYCLOOCTENECARBOXYLICACID RR67387225142022..[](((())))-----------------,
MDL NumberMFCD00242614
EC Number205-815-7
Synonym (6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-3-(Acetoxymethyl)-8-oxo-7-[2-(2-thienyl)acetylamino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R,7R)-3-[(乙酰氧基)甲基]-7-[2-(2-噻吩基)乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 7-(2-Thienylacetamido)cephalosporanic acid 7-(Thiophene-2-acetamido)cephalosporanic acid CEPHALOTHIN Cefalotin Cephalothin {} {hazard_com} Cephalotin 头孢噻吩酸
Chemical Name Translation头孢噻吩
Wiswesser Line NotationT46 ANV ES GUTJ G1OV1 HVQ CMV1- BT5SJ
Beilstein Registry Number0945586
LabNetwork Molecule IDLN00176152
PubChem Substance ID6024
InChIInChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1
Canonical SMILESO=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](NC(CC3=CC=CS3)=O)C1=O)O
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

安全信息

Warnings IRRITANT
RTECSXI0388000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   31(Suppl 3),817,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AACHAX Antimicrobial Agents and Chemotherapy (1961-70).  (Ann Arbor, MI)
   1961-70.  For publisher information, see AMACCQ.  Volume(issue)/page/year:
   -,863,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4296 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 26,44,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   BYYADW Byoin Yakugaku. Hospital Pharmacology.  (Yakuji Nippon Sha, 1-11
   Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1975-
   Volume(issue)/page/year: 3,220,1978

TYPE OF

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 25 ug/plate
REFERENCE :
   ZMMPAO Zentralblatt fuer Bakteriologie, Parasitenkunde,
   Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A:
   Medizinische Mikrobiologie und Parasitologie.  (Stuttgart, Fed. Rep. Ger.)
   V.217-245, 1971-79.  Volume(issue)/page/year: 231,369,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 9 gm/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 14,250,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 18 gm/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 16,250,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8800 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 6),245,19

Storage condition 2-8°C, protect from light

其他信息

  • EPA Substance Registry System:153-61-7(EPA Substance)
  • 灭火剂:水,二氧化碳, 泡沫, 干粉
  • 储运特性:库房低温通风干燥
  • 毒害物质数据:153-61-7(Hazardous Substances Data)
  • 毒性分级:低毒
  • 可燃性危险特性:热分解排出有毒氮氧化物, 硫氧化物烟雾
  • MOL 文件:153-61-7.mol
  • 急性毒性:腹腔-大鼠 LD50: 4296 毫克/公斤; 静脉-小鼠 LD50: 4990 毫克/公斤
  • 类别:有毒物质
  • 用途一:广谱繁殖期杀菌型抗生素，对青霉素酶稳定，抗革兰氏阳性菌作用很强

系列性分类

相关产品推荐