Hypoglycin A (s)-2-氨基-3-((r)-2-亚甲基环丙基)丙酸

CAS 156-56-9 MFCD19203895

化学结构图

156-56-9
SMILES: C=C1CC1CC(N)C(=O)O

化学属性

Mol. FormulaC7H11NO2
Mol. Weight141.17
Melting Point>200 °C
Boiling Point258.21 °C at 760 mmHg

别名和识别编码

Chemical Name(S)-2-Amino-3-((R)-2-methylenecyclopropyl)propanoic acid
CAS Number156-56-9
Synonym Hypoglycin A {LY} Hypoglycin A hypoglycin hypoglycin A hypoglycin, (S)-isomer hypoglycin, carboxy-(14)C-labeled {} {LY} Hypoglycin A {} {} {LY} Hypoglycin A {} {} {} {LY} Hypoglycin A {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoglycin A {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hyp
Chemical Name Translation(s)-2-氨基-3-((r)-2-亚甲基环丙基)丙酸
Wiswesser Line NotationL3YTJ AU1 B1YZVQ
PubChem Substance ID45039541
InChIInChI=1S/C7H11NO2/c1-4-2-5(4)3-6(8)7(9)10/h5-6H,1-3,8H2,(H,9,10)/t5?,6-/m0/s1
Canonical SMILESO=C(O)[C@@H](N)C[C@@H]1C(C1)=C
MDL NumberMFCD19203895
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分类

  • Amino Acids & Derivatives

产品应用

  • A naturally occurring amino acid found in the Ackee (Blighia sapida), concentrated in the fruit of the plant. It is the causative agent of Jamaican Vomiting Sickness.

相关文献及参考

  • Hassall, et al.: Nature, 173, 356 (1954),
  • Hassall, R., et al.: Biochem. J., 60, 334 (1955),
  • Renner, et al.: Helv. Chim. Acta, 41, 589 (1958),

安全信息

RTECSGZ2215000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 121,272,1957

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 121,272,1957

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 121,272,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 97 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WIMJAD West Indian Medical Journal.  (Univ. of the West Indies, Fa

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 3-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   55,39,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 6,813,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 180 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   LSBGAY Life Sciences, Part 2: Biochemistry, General and Molecular Biology.
   (New York, NY)  V.9-13, 1970-73.  For publisher information, see LIFSAK.
   Volume(issue)/page/year: 9,1305,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE

Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P301+P316
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition

系列性分类

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