2,2-Bis(4-glycidyloxyphenyl)propane 2,2-双(4-环氧丙氧基苯基)丙烷

CAS 1675-54-3 MFCD00080480

化学结构图

1675-54-3
SMILES: CC(C)(c1ccc(OCC2CO2)cc1)c1ccc(OCC2CO2)cc1

化学属性

Mol. FormulaC21H24O4
Mol. Weight340.41
Melting Point40-44 °C
Refractive index1.5720 to 1.5750
Density1.16 g/mL at 25 °C(lit.)
TSCAYes
Boiling Point210 °C at 1 mmHg
SolubilitySoluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
Stability对热、湿度敏感

别名和识别编码

Chemical Name2,2-Bis(4-glycidyloxyphenyl)propane
Synonym 2,2-Bis(4-glycidyloxyphenyl)propane {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2-Bis(4-glycidyloxyphenyl)propane
CAS Number1675-54-3
PubChem Substance ID2286
EC Number216-823-5
Beilstein Registry Number299026
MDL NumberMFCD00080480
Reaxys-RN299026
Chemical Name Translation2,2-双(4-环氧丙氧基苯基)丙烷
Wiswesser Line NotationT3OTJ B1OR D- 2X
LabNetwork Molecule IDLN01277313
InChIInChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
Canonical SMILESCC(C1=CC=C(OCC2OC2)C=C1)(C3=CC=C(OCC4OC4)C=C3)C
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Aromatics, B,
  • {SNA} Analytical Reagents, Analytical/Chromatography, Embedding Media, Embedding and Mounting Media, Microscopy Reagents
  • {SNA} B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Reg
  • {

产品应用

  • An inhibitor of PPARγ and suppressor of TNFα.

相关文献及参考

  • 1. J.S. Gandara et al. J. Chromatogr. Sci. 30 , 11, (1992)
  • 2. Chromatographia 34 , 67, (1992)
  • 3. P.P. Losada et al. Fresenius Z. Anal. Chem. 345 , 527, (1993)
  • Merck 14 ,1297
  • Beil. 17 ,V,3,27

安全信息

GHS Symbol
WGK Germany1
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSTX3800000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P333+P313+P362+P364
  • P333+P313
  • P305+P351+P338
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P302+P350
  • P337+P313
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P305+P351+P338+P337+P313
Signal word Warning {} {} {} {} {TCI}
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S2 Keep out of the reach of children 避免儿童触及；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
Storage condition 储存温度2-8℃,充氩保存 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 166 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   26,611,1988

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,1718,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: ORNL-5375

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15600 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolen

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11300 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 4/21/1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2A,2219,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1980 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2A,2219,1981

{haza

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 172,105,1986

其他信息

  • Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. PPAR and RXR Regulators - Gene Regulation and Expression
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BI - BZ - B
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Food Residue Analysis - Food & Beverage Standards
  6. NODGE/BADGE - Food Residue Analysis
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Simple 3-Membered Ring Compounds 简单三元环化合物

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