Tosyllysyl chloromethyl ketone

CAS 2364-87-6 MFCD N/A

化学结构图

2364-87-6
SMILES: Cc1ccc(S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl)cc1

化学属性

Mol. Weight332.88
Mol. FormulaC14H21ClN2O3S

别名和识别编码

Wiswesser Line NotationZ4YVGMSWR D1 -L
Chemical NameTosyllysyl chloromethyl ketone
Synonym N-alpha-Tosyl-L-lysyl-chloromethylketone TLCK Tosyl-L-lysine chloromethyl ketone alpha-Tosyl-L-lysylchloromethyl ketone Tosyllysyl chloromethyl ketone Tosyllysine chloromethyl ketone Benzenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-4-methyl-, (S)-
Beilstein Registry Number2885388
CAS Number2364-87-6
InChIKeyRDFCSSHDJSZMTQ-ZDUSSCGKSA-N
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安全信息

RTECSXT5150000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 3,227,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 3,227,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 7500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 31,278,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 40 mg/kg
SEX/DURATION            : female 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/ye

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 70,60,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 280 mg/kg

系列性分类

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