Sodium Chenodeoxycholate 鹅去氧胆酸钠

CAS 2646-38-0 MFCD00065452

化学结构图

2646-38-0
SMILES: C[C@H](CCC(=O)[O-])[C@H]1CCC2C3C(CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O.[Na+]

化学属性

Mol. FormulaC24H39NaO4
Mol. Weight414.56 g/mol
SolubilitySoluble in water (20 mg/ml), and Aqueous buffers (20 mg/ml).

别名和识别编码

Chemical NameSodium Chenodeoxycholate
MDL NumberMFCD00065452
CAS Number2646-38-0
Synonym 3,7-Dihydroxy-5-cholanic acid 5-Cholanic acid-3,7-diol Chenodeoxycholic acid sodium salt 3α,7α-Dihydroxy-5β-cholanic acid 3α,7α-Dihydroxy-5β-cholanic acid 5β-Cholanic acid-3α,7α-diol Chenodeoxycholic acid sodium salt 5β-Cholanic acid-3α,7α-diol Chenodeoxycholic acid (sodium) Sodium Chenodeoxycholate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID354333736
Chemical Name Translation鹅去氧胆酸钠
InChIKeyWDFRNBJHDMUMBL-OICFXQLMSA-M
LabNetwork Molecule IDLN02126920
Reaxys-RN4898788
Canonical SMILESC[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@H]3O)C
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分类

  • {SNA} Anionic Detergents, Bile Salts, Cell Culture, Detergents N to Z, Detergents by Applications, Drug Delivery-Liposomes, Membrane Protein Solubilization, 去垢剂, 生化试剂
  • {SNA} Anionic Detergents, Bile Salts, Cell Culture, Detergents N to Z, Detergents by Applications, Drug Delivery-Liposomes, Membrane Protein Solubilization, 去垢剂,
  • {SNA} An
  • {SNA} Anionic Detergents, Bile Salts, Cell Culture, Detergents, Detergents N to Z, Detergents by Applications, Drug Delivery-Liposomes, Membrane Protein Solubilization
  • {SNA} Anionic Detergents,

产品应用

  • A bile acid used in rat hepatocyte studies

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
Signal word Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
RTECSFZ2231000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1450 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from small intestine
   Skin and Appendages - hair
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,2499,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,2499,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 114 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,2499,1977

其他信息

  • Chenodeoxycholic Acid, Sodium Salt is a bile acid that has been shown to increase intracellular Ca2+ in isolated rat hepatocyte couplets. Induces a permeability transition in freshly isolated rat liver mitochondria.

系列性分类

  1. Application Areas 应用领域分类
  2. Detergents 去污剂洗净剂
  3. Detergents N to Z - Detergents
  1. Functional Group 官能团索引
  2. carboxylic acid salt

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