Mepazine hydrochloride 哌卡嗪盐酸盐
CAS 2975-36-2 MFCD02975362
化学结构图
SMILES: CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1.Cl
化学属性
| Mol. Formula | C19H22N2S.ClH |
|---|---|
| Mol. Weight | 346.95 |
别名和识别编码
| Chemical Name | Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-,monohydrochloride |
|---|---|
| Chemical Name Translation | 哌卡嗪盐酸盐 |
| Chemicalbook ID | CB3921722 |
| Wiswesser Line Notation | T C666 BN ISJ B1- CT6NTJ A1 &GH |
| Synonym | Pecazine hydrochloride Mepazine chloride Pecazine monohydrochloride 10-((1-Methyl-3-piperidyl)methyl)phenothiazine hydrochloride Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-, hydrochloride Mepazine hydrochloride 1-Pipecoline, 3-(phenothiazin-10-yl)methyl-, hydrochloride |
| CAS Number | 2975-36-2 |
| LabNetwork Molecule ID | LN04620831 |
| PubChem Substance ID | 102907 |
| InChI | InChI=1S/C19H22N2S.ClH/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21;/h2-5,8-11,15H,6-7,12-14H2,1H3;1H |
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相关文献及参考
- [1]. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Behavioral - sleep REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 155 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - body temperature decrease REFERENCE : CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 6,365,1957
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
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