Chlormadinone Acetate 氯地孕酮醋酸盐

CAS 302-22-7 MFCD00056471

化学结构图

302-22-7
SMILES:

化学属性

Mol. FormulaC23H29ClO4
Mol. Weight405
Melting Point212

别名和识别编码

Chemical NameChlormadinone Acetate
CAS Number302-22-7
Synonym 17-alpha-Acetoxy-6-chloro-6,7-dehydroprogesterone 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione 6-Chloro-6-dehydro-17α-acetoxyprogesterone 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate Gestafortin Matrol Menstridyl NSC-92338 17-Acetoxy-6-chloro-6-dehydroprogesterone 6-Chloro-17-acetoxy-4,6-pregnadiene-3,20-dione Verton 6-Chloro-6-dehydro-17-alpha-hydroxyprogesterone acetate 6-Chloro-17-alpha-acetoxy-4,6-pregnadiene-3,20-dione 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione Chlormadinonu 6-Dehydro-6-chloro-17-alpha-acetoxyprogesterone Clordion 6-Chloro-delta(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-acetate Fertiletten 6-Chloro-delta(sup 6)-(17-alpha)acetoxyprogesterone CAP 6-Chloro-pregna-4,6-dien-17-alpha-ol-3,20-dione a Gestafortin Cero 17-alpha-Acetoxy-6-chloro-6-dehydroprogesterone {hazard_c 17-alpha-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione 17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione 6-Chloro-6-dehydro-17α-acetoxyprogesterone 6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate Gestafortin Matrol Menstridyl 6-Chloro-6-dehydro-17-alpha-acetoxyprogesterone Chlormadinon acetate Matrol Skedule TM 6-Chloro-17-alpha-hydroxypregna-4,6-diene-3,20-dione acetate Bovisynchron 6-Chloro-delta(sup 6)-17-acetoxyprogesterone 6-Chloro-17- delta(sup 6)-6-Chloro-17-alpha-acetoxyprogesterone Lutor 17-alpha-Acetoxy-6-chloropregna-4,6-diene-3,20-dione Chloromadinone acetate Menstridyl Luteran Chronosyn Ay 13390-6
MDL NumberMFCD00056471
PubChem Substance ID253660934
Beilstein Registry Number2633614
EC Number206-118-0
Chemical Name Translation氯地孕酮醋酸盐
Wiswesser Line NotationL E5 B666 OV KU MUTJ A1 E1 FV1 FOV1 LG
LabNetwork Molecule IDLN00378911
Reaxys-RN2633614
Merck Number2102
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids,

产品应用

  • Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive.

相关文献及参考

  • Brennan, D.M., et al.: Acta Endocrinol., 44, 367 (1963),
  • Honma., s., et al.: Chem Pharm. Bull., 25 2019 (1977),
  • Usui, T., et al.: Acta Urol. Jpn., 27, 327 (1981),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P308+P313
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
RTECSTU3750000
Signal word
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R60 May impair fertility 可能降低生殖能力
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 639 mg/kg/7Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Endocrine - diabetes mellitus
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 3,167,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 182 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   219,1601,1972

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Endocrine - adrenal cortex hypoplasia
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,571,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Endocrine - adrenal cortex hypoplasia
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,571,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Endocrine - adrenal cortex hypoplasia
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 11,571,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - ataxia
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 30 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 16,1483,1995

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 395,179,1997

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 16,1483,1995

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 17,551,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 600 ug/kg
SEX/DURATION            : female 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # f

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 400 ug/kg
SEX/DURATION            : female 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   INJFA3 International Journal of Fertility.  (Allen Press, 1041 New
   Hampshire,  St., Lawrence, KS 66044)  V.1-    1955- Volume(issue)/page/year:
   9,57,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 320 ug/kg
SEX/DURATION            : female 80 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 18,57,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 80 ug/kg
SEX/DURATION            : female 80 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 18,57,1967

Storage condition <0°C

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