SECOBARBITAL SODIUM SALT 司可巴比妥钠盐

CAS 309-43-3 MFCD00069849

化学结构图

309-43-3
SMILES: C=CCC1(C(C)CCC)C(=O)N=C([O-])NC1=O.[Na+]

化学属性

Mol. FormulaC12H18N2O3.Na
Mol. Weight261.31
SolubilityH2O: soluble
Appearance 司可嘏比妥熔点100℃。钠盐为白色粉末。极易溶于水，溶于乙醇，不溶于乙醚。水溶液呈碱性反应。无臭，味苦。有引湿性。

别名和识别编码

Chemical NameSECOBARBITAL SODIUM SALT
Synonym 5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione Natrium-5,5-allyl-[1-methylbutyl]-barbiturat 5-allyl-5-(1-methylbutyl)-barbituricacisodiumsalt propylmethylcarbinylallylbarbituricacidsodiumsalt 5-Allyl-5-(1-methylbutyl)barbituric acid sodium-potassium salt Quinalbarbitone sodium-potassium salt Seconal sodium-potassium salt evronalsodium 司可巴比妥钠 quinalbarbitonesodium 烯戊巴比妥 SECOBARBITAL SODIUM SALT 5-ALLYL-5-[1-METHYLBUTYL]BARBITURIC ACID SODIUM SALT quinalspan 西可巴比妥 bipinalsodium secobarbital sodium 速可眠 5-Allyl-5-(1-methylbutyl)malonylurea sodium salt meballymalsodium secobarbitalsodium sebar 速可巴比妥 5-allyl-5-(1-methylbutyl)malonylureasodiumsalt 4,6(1h,3h,5h)-pyrimidinetrione,5-(1-methylbutyl)-5-(2-propenyl)-monosodi 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrionemonosodium Immenoctal pramil 4,6(1h,3h,5h)-pyrimidinetrione,5-(1-methylbutyl)-5-(2-propenyl)-monosodium 司可巴比妥钠盐 QUINALBARBITONE SODIUM SALT Meballymal sodium Bipinal sodium 5-Allyl-5-(1-methylbutyl)barbituric acid sodium salt secobarbitalsodium--deaschedule*iiitem 5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6-(1H,3H,5H)-Pyrimidinetrionemonosodiumsalt Evronal sodium 5-Allyl-5(1-methylbutyl)barbituric acid sodium derivative 5-allyl-5(1-methylbutyl)barbituricacidsodiumderivative
MDL NumberMFCD00069849
PubChem Substance ID23677179
CAS Number309-43-3
EC Number206-218-4
Chemical Name Translation司可巴比妥钠盐
Wiswesser Line NotationT6VMVMV FHJ FY3&1 F2U1 &-NA-
InChIInChI=1S/C12H18N2O3.Na/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16;/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17);/q;+1/p-1
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分类

  • Analytical Standards, Analytical/Chromatography, Barbiturates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Neurobiology, Neuroscience, Pharmacologicals, S, Sedative/Hypnotics
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; amide; lactame; 2fragments; ionic
  • {SA} Analytical Standards, Analytical/Chromatography, Barbiturates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,

相关文献及参考

  • Kamien, J.B., et al. Pharmacol. Biochem. Behav. 58 , 983, (1997) 摘要
  • Merck 14 ,8420
  • Short: IV/1b Title: Densities of Liquid Systems: Densities of Binary Aqueous Systems and Heat Capacities of Liquid Systems Author: D'Ans, J.; Surawski, H.; Synowietz, C. Editor: Schäfer, Kl. Source: Landolt-Börnstein, New Series Volume: IV/1b Year: 1977 ISBN: 3-540-08272-7 ISBN: 978-3-540-08272-9 Internet Resource: DOI:10.1007/b20004 RefComment: 62 figs., VII, 335 pages. Hardcover Abstract: Volume IV/1 contains information on the densities of liquid systems. It may be considered as a supplement to volume II/1 of the 6th Edition, which contains only a few data on nonaqueous systems. Data are not listed for all systems but primarily for those of greater interest where data for a larger range of concentrations were available.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

RTECSCP9800000
WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Hazard Codes T
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing GroupIII
Hazard Class6.1(b)
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
UN Number UN 2811 6.1/PG 3
Restrict 精神药品 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,401,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 32,1563,1935

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
S

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 133 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 per

其他信息

  • Sigma Aldrich:309-43-3(sigmaaldrich)
  • MOL 文件:309-43-3.mol
  • 用途一:短效类嘏比妥催眠药。作用较快，服后15min可显效，作用持续时间较短，仅2-3h，主要由肝内代谢，对入睡困难者尤为效，用于失眠及麻醉前给药。

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs of Abuse - Forensic and Veterinary Standards
  6. Chemical Structure - Drugs of Abuse
  7. Barbiturates - Chemical Structure

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