(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol hydrochloride 盐酸右旋麻黄素

CAS 345-78-8 MFCD00058088

化学结构图

345-78-8
SMILES: CN[C@@H](C)[C@@H](O)c1ccccc1.Cl

化学属性

Mol. FormulaC10H15NO.ClH
Mol. Weight201.72
Melting Point181-185 °C

别名和识别编码

Chemical Name(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol hydrochloride
CAS Number345-78-8
Synonym alpha-(1-(methylamino)e [1S,2S]-( First sign Benzenemethanol, α-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (αS)- {Chemical (+)-伪麻黄碱 盐酸盐 L-(+)-Pseudoephedrine hydrochloride (+)-Pseudoephedrin Hydrochlorid ######## (+)-PSEUDOEPHEDRINE HYDROCHLORIDE alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r* Pseudoephedrin Hydrochlorid {Chemi (1S,2S)-(+)-pseudoephedrinhydrochlorid Sudafed 1S,2S-(+)-Pseudoephedrine hydrochloride (1S,2S)-(+)-Pseudoephedrine hydrochloride Novafed (1S,2S)-2-(METHYLAMINO)-1-PHENYL-1-PROPANOL HYDROCHL φ-Ephedrinhydrochlo 盐酸异麻黄素 (+)-Pseudoephedrin-hydrochlorid D-PSEUDOEPHEDRINE HYDROCHLORIDE (+)-ψ-麻黄碱 盐酸盐 (1S,2S)-2-甲氨基-1-苯丙醇 盐酸盐 d-伪麻黄碱 盐酸盐 d-异麻黄碱 盐酸盐 (1S,2S)-(+)-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride Sudomyl Pseudoephedrine, hydrochloride, L-(+)- Pseudoephedrine, hydrochloride, (+)- Besan Benzenemethanol, α-[1-(methylamino)ethyl]-, hydrochloride, [S-(R*,R*)]- (1S,2S)-(+)-Pseudoephedrine hydro benzenemethanol,alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,thet d-[α-(1-Methylamino)ethyl]benzyl alcohol hydrochloride PSEUDOEPHEDRINE HYDROCHLORIDE PSEUDOEPHEDRINE HCL, (+)-1S,2S- (+)-1S,2S-PSEUDOEPHEDRINE HCL d-Pseudoephedrine hydrochloride (1S,2S)-(+)-PSEUDOEPH (+)-Pseudoephedrine hydrochloride ISOEPHEDRINE HYDROCHLORIDE l(+)-pseudoephedrinehydrochloride (1S,2S)-2-METHYLAMINO-1-PHENYLPROPANOL HYDROCHLORIDE {Chemicalbo 盐酸右旋麻黄素
Beilstein Registry Number3915112
PubChem Substance ID9581
EC Number206-462-1
MDL NumberMFCD00058088
Chemical Name Translation盐酸右旋麻黄素
Merck Number13,8007
Wiswesser Line NotationQYR&Y1&M1 &GH -L
InChIInChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10+;/m0./s1
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分类

  • Alkaloid, Alkaloids, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Ephedrine, Forensic and Veterinary Standards, Neat Compounds, Neurobiology, Neuroscience, Neurotransmission (Obesity), Nutrition Research, Obesity Research, P, Pharmacologicals, Phytochemicals by Chemical Classification, Stimulants
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; alcohol; chiral; 2fragments; ionic
  • {SA} Alkaloid,
  • {SNA} Alkaloid,

产品应用

  • Non-selective adrenergic agonist; decongestant (nasal).

相关文献及参考

  • Fairchild, M.D., et al.: J. Pharmacol. Exp. Ther., 158, 135 (1967),
  • Hughes, D.T.D., et al.: J. Clin. Hosp. Pharm., 8, 315 (1983),
  • Gurley, B.J., et al.: J. Pharm. Sci., 87, 1547 (1998),
  • Kumarnsit, E., et al., Pseudoephedrine, a sympathomimetic agent, induces Fos-like immunoreactivity in rat nucleus accumbens and striatum. Neuropharmacology 38 , 1381-1387, (1999) 摘要
  • Merck 14 ,7916
  • Beil. 13 ,IV,1878
  • Corp MSDS 1 (2), 2983:D / FT-NMR 1 (2), 579:B / RegBook 1 (1), 1471:F / Sax 6 , 2320 / Sigma FT-IR 1 (1), 586:D / Structure Index 1 , 230:A:2
  • Short: IV/1b Title: Densities of Liquid Systems: Densities of Binary Aqueous Systems and Heat Capacities of Liquid Systems Author: D'Ans, J.; Surawski, H.; Synowietz, C. Editor: Schäfer, Kl. Source: Landolt-Börnstein, New Series Volume: IV/1b Year: 1977 ISBN: 3-540-08272-7 ISBN: 978-3-540-08272-9 Internet Resource: DOI:10.1007/b20004 RefComment: 62 figs., VII, 335 pages. Hardcover Abstract: Volume IV/1 contains information on the densities of liquid systems. It may be considered as a supplement to volume II/1 of the 6th Edition, which contains only a few data on nonaqueous systems. Data are not listed for all systems but primarily for those of greater interest where data for a larger range of concentrations were available.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Precautionary statements
  • P305+P351+P338
WGK Germany3
GHS Symbol
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSUL5950000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Packing GroupIII
Hazard Class6.1(b)
Storage condition Refrigerator (+4°C)
UN Number 1544
Restrict 易制毒化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 714 ug/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 39,404,1927

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
   Washington, DC, National Academy of Sciences, 1972-77
   Volume(issue)/page/year: Mn,128,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MAIZAB Manshu Igaku Zasshi.  Manchuria Medical Journal. (Dairen/Shimmeicho,
   South Manchuria) V.1-33, 1923-40.  Discontinued. Volume(issue)/page/year:
   3,1,1925

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : R

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 71,62,1941

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其他信息

  • MSDS 信息:(1S,2S)-(+)-Pseudoephedrine hydrochloride(345-78-8).msds
  • MOL 文件:345-78-8.mol
  • 比旋光度:61 ° (c=5, H2O,2dm tube)
  • 用途一:常用于治疗支气管哮喘、喘息性支气管炎、慢性支气管炎和肺气肿等病症。
  • Acros Organics:(1S,2S)-(+)-Pseudoephedrinehydrochloride,99+%(345-78-8)
  • Sigma Aldrich:345-78-8(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Alkaloid - Phytochemicals by Chemical Classification
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs of Abuse - Forensic and Veterinary Standards
  6. Chemical Structure - Drugs of Abuse
  7. Ephedrine - Chemical Structure
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids

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