Acepromazine maleate, 97% 马来酸乙酰丙嗪
CAS 3598-37-6 MFCD00082473
化学结构图
SMILES: CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2.O=C(O)/C=C\C(=O)O
化学属性
| Mol. Formula | C19H22N2OS.C4H4O4 |
|---|---|
| Mol. Weight | 442.53 g/mol |
| Melting Point | 136-140 |
别名和识别编码
| Chemical Name | Acepromazine maleate, 97% |
|---|---|
| CAS Number | 3598-37-6 |
| Synonym | Acepromazine Maleate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 1-[10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethan-1-one Maleate, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine Maleate Salt |
| MDL Number | MFCD00082473 |
| EC Number | 222-748-9 |
| Chemical Name Translation | 马来酸乙酰丙嗪 |
| Wiswesser Line Notation | T C666 BN ISJ B3N1&1 EV1 &OV1U1VO |
| PubChem Substance ID | 6420038 |
| LabNetwork Molecule ID | LN00342655 |
| InChI | InChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
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分类
- A-AM, Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Kinase/Phosphatase Biology, Membrane Protein Biology Tools,
产品应用
- A tranquilizer.
相关文献及参考
- Wirth, W., et al.: Arch. Int. Pharmacodyn, 123, 78 (1959),
- Dyson, H., et al.: Can.Vet. J., 33, 462 (1992),
- Nogueira, R.B., et al., Effects of sedation with acepromazine maleate and buprenorphine hydrochloride on femoral artery blood flow in healthy dogs Res. Vet. Sci. 93(2) , 989-92, (2011)
- Mouney, M.C., et al., Effects of acepromazine maleate or morphine on tear production before, during, and after sevoflurane anesthesia in dogs Am. J. Vet. Res. 72 , 1427-30, (2011)
- Kamine, A., et al., Changes in blood glucose and insulin responses to intravenous glucose tolerance tests and blood biochemical values in adult female Japanese black bears (Ursus thiβnus japonicus). Jpn. J. Vet. Res. 60 , 5-13, (2012)
- Zhang Y., et al, A previously unidentified acepromazine metabolite in humans: implications for the measurement of acepromazine in blood. Cancer Res. 14 , 567-575, (2009)
- Davalos D., et al.,, Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J. Neurosci. Methods 1 , 1-7, (2008) 摘要
- Merck 14 ,32
安全信息
GHS Symbol
- P301+P310+P330
- P304+P340+P312
- P403+P233
- H302 Harmful if swallowed 吞食有害
- H302+H312+H332
- H312 Harmful in contact with skin 皮肤接触有害
- H332 Harmful if inhaled 吸入有害
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S22 Do not breathe dust 不要吸入粉尘；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R50/53
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Or
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 6250 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,247,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962
{hTYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 175 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
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