2,4,7-Triamino-6-Phenylpteridine 氨苯蝶啶

CAS 396-01-0 MFCD00006708

化学结构图

396-01-0
SMILES: Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

化学属性

Mol. FormulaC12H11N7
Mol. Weight253.30
Melting Point>300°
TSCANo
Solubility<0.1 G/100 ML AT 20 ºC
Flash Point11 °C
Appearance 黄色结晶性粉末。熔点316℃(327℃),极微溶于冰乙酸,几乎不溶于水、乙醇、氯仿。无臭或几乎无臭,无味。

别名和识别编码

Chemical Name2,4,7-Triamino-6-Phenylpteridine
CAS Number396-01-0
Alfabeta NamePHENYLPTERIDINETRIAMINE 6247---,,
MDL NumberMFCD00006708
Synonym 2,4,7-三氨基-6-苯基喋啶 ncic56042 ditak 7-pteridinetriamine,6-phenyl-4 6-Phenyl-2,4,7-triaminopteridine 6-PHENYL-2,4,7-PTERIDINETRIAMINE Pterofen Noridil 2,4,7-Triamino-6-phenylpteridine Ditak Triamteril 6-PHENYL-PTERIDINE-2,4,7-TRIAMINE 氨苯喋啶 NCI C56042 Triamterene Jatropur dytac 氨苯蝶啶 Triteren Taturil 6-苯基-2,4,7-三氨基蝶啶 dyren Dytac 三氨喋啶 Triampur dyrenium noridil Teriam ADEMINE 2,4,7-TRIAMINO-6-PHENYLPTERIDINE Diren pterofen 氨喋啶 Tri-Span 2,4,7-Triamino-6-phenylpteridine; 6-Phenyl-2,4,7-pteridinetriamine 三氨蝶啶 2,4,7-Pteridinetriamine, 6-phenyl- 苯并碟碇 2,4,7-triamino-6-phenyl-pteridin noridyl diurene Dyrenium 6-苯基-2,4,7-蝶啶三胺 SKF 8542 6-Phenyl-2,4,7-pteridinetriamine jatropur 2,4,7-triamino-6-fenilpteridina Triamteril complex diren TRIAMTERENE Triamteren Teridin 6-PHENYL-2,4,7-TRIAMINO PTERIDINE Ademine 2,4,7-Triamino-6-fenilpteridina Pterophene 2,4,7-三氨基-6-苯基蝶啶 6-Phenyl-
PubChem Substance ID5546
EC Number206-904-3
Merck Number14,9599
Beilstein Registry Number0266723
Chemical Name Translation氨苯蝶啶
Wiswesser Line NotationT66 BN DN GN JNJ CZ EZ HR& IZ
LabNetwork Molecule IDLN00157338
InChIInChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
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分类

  • Aromatics
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, T, Voltage-gated Ion Channels, Wellspring

产品应用

  • Triamterene is a weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

相关文献及参考

  • [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41.
  • Kapoor, V.K., et al.: Anal. Profiles Drug Subs. Excip., 23, 571 (1994),
  • Osdene, et al.: J. Med. Chem., 10, 431 (1967),
  • [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.
  • [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.
  • [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41.

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSUO3470000
Signal word Danger Warning
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S24 Avoid contact with skin 避免皮肤接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
Hazard Codes Xn Xn,T,F
Packing GroupIII
Hazard Class6.1(b)
Storage condition 2-8°C
UN Number 2811
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21840 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-420,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34944 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-420,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 35,1688,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,519,1982

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 42 mg/kg/3W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 147,262,1987

TY

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRXXBL French Demande Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2314719

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 12600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 25 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   6),4,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2800 ug/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 12600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

其他信息

  • 上游原料:氰乙酸乙酯 --> 乙醇钠 --> 乙二胺四乙酸二钠盐 --> 氰苄 --> 2,4,6-三氨基嘧啶
  • TCI Shanghai:氨苯蝶啶 Triamterene,>;98.0%(T)(396-01-0)
  • 图谱信息:2,4,7-三氨基-6-苯基蝶啶(396-01-0)红外图谱(IR1) 2,4,7-三氨基-6-苯基蝶啶(396-01-0)质谱(MS) 2,4,7-三氨基-6-苯基蝶啶(396-01-0)红外图谱(IR2)
  • 方法一:5-亚硝基-2,4,6-三氨基嘧啶和无水乙醇一起回流1h,加入部分量氰苄和乙醇钠,回流2h后再加入其余量氰苄和乙醇钠,继续回流5h,冷却至10℃左右,过滤,用沸水洗涤,得氨苯蝶啶粗品。将粗品、浓硫酸及活性炭加入水中,回流45min,趁热过滤,滤液加热至沸,加入ED-TA二钠盐,用浓氨水调节至pH9,过滤,洗涤,干燥,得成品。
  • MSDS 信息:2,4,7-Triamino-6-phenylpteridine(396-01-0).msds
  • 用途一:弱效利尿药。作用迅速而短暂,口服后2h开始利尿,6h达高峰,作用持续8-12h,临床用于心力衰竭,肝硬化和慢性肾炎等引起的顽固性水肿或腹水,亦用于对氢氯噻嗪 或螺内酯无产的病例。该品有排除尿酸作用,适用于治疗痛风。
  • Sigma Aldrich:396-01-0(sigmaaldrich)
  • Alfa Aesar:2,4,7-三氨基-6-苯基蝶啶,98% 2,4,7-Triamino-6-phenylpteridine, 98%(396-01-0)
  • MOL 文件:396-01-0.mol
  • 氨苯蝶啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B20044 2,4,7-三氨基-6-苯基蝶啶, 98% 2,4,7-Triamino-6-phenylpteridine, 98% 5g 412元 2010/05/25 B20044 2,4,7-三氨基-6-苯基蝶啶, 98% 2,4,7-Triamino-6-phenylpteridine, 98% 25g 853元 2010/05/25 B20044 2,4,7-三氨基-6-苯基蝶啶, 98% 2,4,7-Triamino-6-phenylpteridine, 98% 100g 2730元

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