Desomorphine

CAS 427-00-9 MFCD00864242

化学结构图

427-00-9
SMILES: CN1CC[C@]23c4c5ccc(O)c4O[C@H]2CCC[C@H]3[C@H]1C5

化学属性

Mol. FormulaC17H21NO2
Mol. Weight271.39

别名和识别编码

Chemical NameMorphinan-3-ol, 4,5-alpha-epoxy-17-methyl-
CAS Number427-00-9
Synonym (5?)-4,5-Epoxy-17-methylmorphinan-3-ol 4,5-Epoxy-3-hydroxy-N-methylmorphinan 6-Deoxy-7,8-dihydromorphine Deoxydihydromorphine D Desomorfin Desomorphine Dihydro Dihydrodeoxymorphine Dihydrodesoxymorphine D Dihydrodesoxymorphine-D Morphine, 6-deoxy-7,8-dihydro- Permonid desomorphine krokodil
Wiswesser Line NotationT B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ JQ P1
PubChem Substance ID5362456
InChIInChI=1S/C17H21NO2/c1-18-8-7-17-11-3-2-4-14(17)20-16-13(19)6-5-10(15(16)17)9-12(11)18/h5-6,11-12,14,19H,2-4,7-9H2,1H3/t11-,12+,14-,17+/m0/s1
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分类

  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Analgesic (narcotic).

相关文献及参考

  • Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007),
  • Zhao, M., et al.: Eur. J. Med. Chem., 43, 1048 (2008),
  • Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009),

安全信息

RTECSQD1730000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 84,268,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 104 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 55,257,1935

Hazard statements
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
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