Tabersonine (3aR,3a1S,10bR)-3a-乙基-3a,3a1,4,6,11,12-六氢-1H-吲哚并[8,1-cd]咔唑-5-羧酸甲酯

CAS 4429-63-4 MFCD28140545

化学结构图

4429-63-4
SMILES: CC[C@@]12C=CCN3CC[C@@]4(C(=C(C(=O)OC)C1)Nc1ccccc14)[C@H]32

化学属性

Mol. FormulaC21H24N2O2
Mol. Weight336
Melting Point79-81

别名和识别编码

Chemical NameTabersonine
CAS Number4429-63-4
Synonym (-)-Tabersonine (-)-Tabersonine (5α,12β,19α)-2,3,6,7-tetrahydro-aspidospermidine-3-carboxylic acid methyl ester, Tabersonin 3a-Ethyl-3a,4,6,11,12,13a-hexahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylic Acid Methyl Ester Tabersonin Tabersonine 它勃宁; 柳叶水甘草碱
EC Number224-615-0
Chemical Name Translation(3aR,3a1S,10bR)-3a-乙基-3a,3a1,4,6,11,12-六氢-1H-吲哚并[8,1-cd]咔唑-5-羧酸甲酯
InChIKeyFNGGIPWAZSFKCN-ACRUOGEOSA-N
Beilstein Registry Number0050163
MDL Number
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • (-)-Tabersonine is one of the terpenoid indole alkaloids (TIAs) from Catharanthus roseus. (-)-Tabersonine shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.

相关文献及参考

  • Vachnadze, V., et al.: Pharm. Chem. J., 44, 199 (2010),
  • Ferreres, F., et al.: J. Pharm. Biomed. Anal., 51, 65 (2010),

安全信息

RTECSCJ0150000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 13,123,1955

GHS Symbol
Signal word Warning
Precautionary statements
  • P301+P312+P330

系列性分类

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