Doxylamine 多西拉敏

CAS 469-21-6 MFCD00599469

化学结构图

469-21-6
SMILES: CN(C)CCOC(C)(c1ccccc1)c1ccccn1

化学属性

Mol. FormulaC17H22N2O
Mol. Weight270.41

别名和识别编码

Chemical NameDoxylamine
Synonym Ethanamine, N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)- Doxylamine NCI C60684 2-Dimethylaminoethoxyphenylmethyl-2-picoline Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
Wiswesser Line NotationT6NJ BX1&R&O2N1&1
CAS Number469-21-6
Beilstein Registry Number0230379
Chemical Name Translation多西拉敏
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安全信息

RTECSUS9250000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982

TYPE OF TEST

{ha

系列性分类


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