Telocinobufogenin 端粒细胞生成素

CAS 472-26-4 MFCD00472264

化学结构图

472-26-4
SMILES: C[C@]12CC[C@@H]3[C@@H](CC[C@]4(O)C[C@@H](O)CC[C@]34C)[C@@]1(O)CC[C@@H]2c1ccc(=O)oc1

化学属性

Mol. Weight402.52
Mol. FormulaC₂₄H₃₄O₅
Density1.311

别名和识别编码

CAS Number472-26-4
Chemical NameTelocinobufogenin
Synonym (3?,5?)-3,5,14-Trihydroxybufa-20,22-dienolide 3-beta,5,14-Trihydroxy-5-beta-bufa-20,22-dienolide 3?,5,14-Trihydroxy- 5?-bufa-20,22-dienolide NSC 119989 NSC 90782 Telobufotoxin Telobufotoxin; Telocinobufogenin; (3beta,5beta)-3,5,14-Trihydroxybufa-20,22-dienolide Telocinobufagin Telocinobufogenin {} {} {PubChem} telocinobufagin
Chemical Name Translation端粒细胞生成素
Wiswesser Line NotationL E5 B666TJ A1 E1 IQ MQ OQ F- ET6OVJ
Beilstein Registry Number0056287
InChIKeyPBSOJKPTQWWJJD-ZBDZJSKLSA-N
LabNetwork Molecule IDLN01306656
PubChem Substance ID259991
InChIInChI=1S/C24H34O5/c1-21-9-5-16(25)13-23(21,27)11-7-19-18(21)6-10-22(2)17(8-12-24(19,22)28)15-3-4-20(26)29-14-15/h3-4,14,16-19,25,27-28H,5-13H2,1-2H3/t16-,17+,18-,19+,21+,22+,23-,24-/m0/s1
MDL Number
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids

产品应用

  • Telocinobufagin is isolated as a major component from skin secretion of the toad Bufo rubescens. Telocinobufogenin is a novel antibiotic cardiotonic.

相关文献及参考

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安全信息

RTECSEI2996700 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1102 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHUZBI Pharmazie in Unserer Zeit.  (VCH Pub., Inc., 303 N.W. 12th Ave.,
   Deerfield Beach, FL 33441) V.1-    1972-  Volume(issue)/page/year:
   13,129,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4340 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
   Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963  Volume(issue)/page/year:
   -,194,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 102 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHUZBI Pharmazie in Unserer Zeit.  (VCH Pub., Inc., 303 N.W. 12th Ave.,
   Deerfield Beach, FL 33441) V.1-    1972-  Volume(issue)/page/year:
   13,129,1984

Storage condition 4

系列性分类

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