4-Isopropyl-1,5-Dimethyl-2-Phenyl-1H-Pyrazol-3(2H)-One 4-异丙基-1,5-二甲基-2-苯基-1H-吡唑-3(2H)-酮

CAS 479-92-5 MFCD00053368

化学结构图

479-92-5
SMILES: Cc1c(C(C)C)c(=O)n(-c2ccccc2)n1C

化学属性

Mol. FormulaC14H18N2O
Mol. Weight230.31
Melting Point102.0 to 106.0 deg-C

别名和识别编码

Chemical Name4-Isopropyl-1,5-Dimethyl-2-Phenyl-1H-Pyrazol-3(2H)-One
CAS Number479-92-5
Synonym 异丙安替比林 1,5-二甲基-4-异丙基-2-苯基-1,2-二氢-3H-吡唑-3-酮 3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- 2,3-dimethyl-4-isopropyl-1-phenyl-3-pyrazolin-5-on 1,2-二氢-1,5-二甲基-4-异丙基-2-苯基-3H-吡唑-3-酮 ######## 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- Larodon 4-ISOPROPYL-2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE ISOPROPYLANTIPYRINUM Isopropylantipyrine Isopropylphenazone 4-ISOPROPYL-1,5-DIMETHYL-2-PHENYL-3-PYRAZOLONE 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-Pyrazol-3-one ISOPROPYLPHENAZONE 4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one PROPYPHENAZONE 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one Propyphenazone 1-phenyl-2,3-dimethyl-4-isopropyl-5-Pyrazolone 4-ISOPROPYLANTIPYRINE 3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl- ISOPROPYLANTIPYRINE 3,3-二甲基-2-亚甲基降莰烷 Isopropylantipyrin 3-Pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl- 2,3-Dimethyl-4-isopropyl-1-phenyl-3H-pyrazolin-5-one 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Isopropyrine 1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one 2,2-二甲基-3-亚甲基降茨烷 4-Isopropylantipyrine 1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one Isopropylantipyrine; 1,5-Dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
MDL Number
EC Number207-539-2
Beilstein Registry Number24(5)1,408
Reaxys-RN204533
PubChem Substance ID3778
Merck Number7871
Chemical Name Translation4-异丙基-1,5-二甲基-2-苯基-1H-吡唑-3(2H)-酮
Wiswesser Line NotationT5NNVJ A1 BR& DY1&1 E1
LabNetwork Molecule IDLN01307736
InChIInChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Analgesic; antipyretic; anti-inflammatory.

相关文献及参考

  • Ertl, P., et al.: J. Med. Chem., 43, 3714 (2000),
  • Sun, C., et al.: J. Pharm. Sci., 93, 646 (2004),

安全信息

RTECSCD2800000
Signal word
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 61,205,1937

TYPE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 84,351,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 9,401,1959

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 61,205,1937

TYPE OF TEST            : LD

其他信息

  • 图谱信息:异丙安替比林(479-92-5)红外图谱(IR2) 异丙安替比林(479-92-5)质谱(MS) 异丙安替比林(479-92-5)红外图谱(IR1) 异丙安替比林(479-92-5)核磁图( 1 HNMR) 异丙安替比林(479-92-5)核磁图( 13 CNMR)
  • MOL 文件:479-92-5.mol
  • TCI Shanghai:4-异丙基安替比林 4-Isopropylantipyrine,>;98.0%(GC)(479-92-5)
  • 异丙安替比林价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 I0656 4-异丙基安替比林 4-Isopropylantipyrine 25G 291元 2014/06/02 I0656 4-异丙基安替比林 4-Isopropylantipyrine 250G 1250元

系列性分类

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