Nialamide 尼亚酰铵
CAS 51-12-7 MFCD00010106
化学结构图
SMILES: O=C(CCNNC(=O)c1ccncc1)NCc1ccccc1
化学属性
| Mol. Formula | C16H18N4O2 |
|---|---|
| Mol. Weight | 298 |
| Melting Point | 152-154 °C(lit.) |
别名和识别编码
| Chemical Name | Nialamide |
|---|---|
| CAS Number | 51-12-7 |
| MDL Number | MFCD00010106 |
| Synonym | {uni_hamburg} 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid 4-Pyridinecarboxylic acid, 2-[3-oxo-3-[(phenylmethyl)amino]propyl]hydrazide nialamide Delmoneurina N-Benzyl-beta-(isonicotinoylhydrazine)propionamide isonicotinic acid 2-[2-(benzylcarbamoyl)ethyl]hydrazide N-Benzyl-β-(isonicotinoylh Novazid Niamidal 1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼 N-苄基-β-(异烟肼)丙酰胺 吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼 Niaquitil Espril Isonicotinic acid, 2-[2-(benzylcarbamoyl)ethyl]hydrazide Nuredal N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide N-Isonicotinoyl-N'(beta-N-benzylcarboxamidoethyl)hydrazine Isalizina Surgex 4-pyridinecarboxylic acid 2-[3-oxo-3-[(phenylmethyl) amino]propyl]hydrazide 2-[2-(Benzylcarbamoyl)ethyl]hydrazide isonicotinic acid Nyazin Niamid 尼亚酰铵 Niamide N1-Beta-Benzylcarbamoyl-ethyl-N2-isonicotinoyl-hydrazine BEIH N-benzyl-3-(2-isonicotinoylhydrazino)propionami Mygal 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine Delmoneurinaesprilisalizina N1-β-Benzylcarbamoylethyl-N2isonicotinoylhydrazine N-Isonicotinoyl-N'-(β-N-benzylcarboxamidoethyl)hydrazine Isonicotinic acid, 2-[2-(benzylcarbamoylethyl]hydrazide N-Benzyl-β-(isonicotinylhydrazino)propionamide N(sup 1)-beta-Benzylcarbamoylethyl-N(sup 2)-isonicotinoylhydrazine Niazin N-Benzyl-beta-(isonicotinylhydrazino)propionamide P 1133 Psicodisten Nialamide {uni_hamb |
| PubChem Substance ID | 4472 |
| EC Number | 200-079-3 |
| Beilstein Registry Number | 492941 |
| Chemical Name Translation | 尼亚酰铵 |
| Wiswesser Line Notation | T6NJ DVMM2VM1R |
| LabNetwork Molecule ID | LN00239281 |
| InChI | InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22) |
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分类
- {SA} Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C16+, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Heterocyclic Building Blocks, L to O, Monoamine Oxidase, Monoamine oxidase inhibitor, N, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pyridines
- {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; amide; 1fragment
- {SNA} Building Blocks, C16+, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
相关文献及参考
- Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H351 Suspected of causing cancer 怀疑致癌
- H319 Causes serious eye irritation 严重刺激眼睛
- H302+H312+H332
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S22 Do not breathe dust 不要吸入粉尘；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 25,158,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE :
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1700 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TXAPA9 Toxicology an
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publi
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 760 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,524,1959
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 435 mg/kg REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health.
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 2450 umol/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1469,1981
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,305,1976
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 ug/plate REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 12,423,1980
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 27 umol/plate REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,287,1982
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 10 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 24 mg/kg SEX/DURATION : female 1-6 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 27,147,1963
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