Prednisolone Acetate 醋酸泼尼松龙

CAS 52-21-1 MFCD00037710

化学结构图

52-21-1
SMILES: CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

化学属性

Mol. FormulaC23H30O6
Mol. Weight402.53
Melting Point240-244
Refractive index112 ° (C=1, Dioxane)
SolubilityDMSO 81 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

别名和识别编码

Chemical NamePrednisolone Acetate
CAS Number52-21-1
Synonym {Chemicalbook} 乙酸去氢皮质醇 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione Prednisolone 21-acetate 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE Supercortyl 11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate 1,4-孕甾二烯-11β,17α,21-三醇-3,20-二酮 21-醋酸酯;11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮 21-醋酸酯;21-乙酰氧基-1,4-孕甾二烯-11β,17α-二醇-3,20-二酮 ######## 乙酸强的松龙 1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE PREDNISOLONE 21-ACETATE 1,4-孕甾二烯-11β,17α,21-三醇-3,20-二酮 21-醋酸酯 11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮 21-醋酸酯 21-乙酰氧基-1,4-孕甾二烯-11 醋酸去氢氢化可的松 Prednidoren 1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE Prediacortine {hazard_c (11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione INFLANEFRAN 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione 1-DEHYDROCORTISOL 21-ACETATE Prenema Cormalone 11b,17a,21-三 11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate PREDNISOLONE ACETATE 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate 醋酸氢化泼尼松 Prednelan-N 11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE 17-Dol-3,20-dione 乙酸脱氢皮质醇 Meticortelone acetate
MDL NumberMFCD00037710
PubChem Substance ID5834
Beilstein Registry Number3111798
EC Number200-134-1
Chemical Name Translation醋酸泼尼松龙
Merck Number7721
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ
LabNetwork Molecule IDLN01312579
InChIInChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Clinical Standards, Hormones, Market Segments, Neats and Solutions, P, PON - PT, Standards for Food and Beverage Analysis, Standards for Pharma Clinical Forensic & Veterinary Analysis
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments, Chromatography, Clinical Standards, Hormones, Neats and Solutions, P, PON - PT, Pharma
  • {SNA} Cell Signaling and Neuroscience, Corticosteroid, Cytok

产品应用

  • Synthetic corticosteroid; metabolically interconvertible with prednisone.

相关文献及参考

  • Jusko, W.J., et al.: Ther. Drug Monit., 2, 169 (1980),
  • Ali, S.L., et al.: Anal. Profiles Drug Subs. Excip., 21, 415 (1992),
  • Merck 14 ,7721
  • Beil. 8 ,IV,3468

安全信息

RTECSTU4152500
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P310
Hazard statements
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Signal word
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
UN Number UN 2811 6.1/PG 3
Storage condition 储存温度-20°C
Packing GroupIII 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,713,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,713,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 2-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 22,735,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 96 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,245,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 96 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including

其他信息

  • 用途一:适用于类风湿关节炎、风湿热、红斑狼疮、硬皮病、皮肌炎、急性淋巴白血病等。
  • 图谱信息:醋酸泼尼松龙(52-21-1)核磁图( 1 HNMR) 醋酸泼尼松龙(52-21-1)红外图谱(IR2) 醋酸泼尼松龙(52-21-1)红外图谱(IR1) 醋酸泼尼松龙(52-21-1)核磁图( 13 CNMR) 醋酸泼尼松龙(52-21-1)质谱(MS)
  • MOL 文件:52-21-1.mol
  • 醋酸泼尼松龙
  • Sigma Aldrich:52-21-1(sigmaaldrich)
  • TCI Shanghai:乙酸泼尼松龙 Prednisolone Acetate,>;95.0%(LC)(52-21-1)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Complex Molecules - Chiral Building Blocks
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Market Segments - Analytical Standards
  4. Standards for Pharma Clinical Forensic &amp; Veterinary Analysis - Market Segments
  5. Neats and Solutions - Standards for Pharma Clinical Forensic &amp; Veterinary Analysis
  6. Hormones - Neats and Solutions
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Corticosteroid - Steroid Hormones
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids

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