9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline 9,10-二甲氧基-5,8,13,13a-四氢-6H-[1,3]二氧戊环并[4,5-g]异喹啉并[3,2-a]异喹啉

CAS 522-97-4 MFCD00067284

化学结构图

522-97-4
SMILES: COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1C2)OCO4

化学属性

Mol. Weight339.39
Mol. FormulaC₂₀H₂₁NO₄
Melting Point>167°C (dec.)
Boiling Point
Flash Point-

别名和识别编码

CAS Number522-97-4
Chemical Name9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
Synonym 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine Canadine
EC Number208-338-2
Chemical Name Translation9,10-二甲氧基-5,8,13,13a-四氢-6H-[1,3]二氧戊环并[4,5-g]异喹啉并[3,2-a]异喹啉
PubChem Substance ID34458
InChIInChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3
LabNetwork Molecule IDLN00346571
MDL Number-
Canonical SMILES-
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分类

  • Aromatics
  • Heterocycles
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditi

相关文献及参考

  • [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.
  • Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010),
  • Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006),
  • Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009),
  • [1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
  • [1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
  • [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

安全信息

GHS Symbol
Signal word
Precautionary statements
Storage condition +4 4 4°C

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor  (多巴胺受体)

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