Trihexyphenidyl hydrochloride 盐酸苯海索

CAS 52-49-3 MFCD00052493

化学结构图

52-49-3
SMILES: Cl.OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1

化学属性

Mol. FormulaC20H31NO.HCl
Mol. Weight337.93 g/mol

别名和识别编码

Chemical NameTrihexyphenidyl hydrochloride
Chemical Name Translation盐酸苯海索
Chemicalbook IDCB4447818
Wiswesser Line NotationT6NTJ A2XQR&- AL6TJ &GH
Synonym 3-(1-Piperidyl)-1-cyclohexyl-1-phenyl-1-propanol hydrochloride Artane Benzhexol chloride Pacitane Paralest Parkinsan Pipanol Romparkin Tremin Trihexylphenidy HCl Trihexyphenidyl Hydrochloride {} {} {} {} {} {} {} {} {hazard_com} alpha-Cyclohexyl-alpha-phenyl-1-piperidinepropanol hydrochloride {} {} {} {} {} {} {} {} {} {hazard_com} Trihexyphenidyl hydrochloride
CAS Number52-49-3
Beilstein Registry Number5667971
LabNetwork Molecule IDLN00196517
MDL NumberMFCD00058212
Reaxys-RN5667971
Merck Number9695
PubChem Substance ID253661351
InChIInChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
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安全信息

RTECSTN2625000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent -

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,311,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 217 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,525,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1630 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (4),40,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volu

GHS Symbol
UN Number 3077
Hazard Codes 9
Signal word Warning
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII
Hazard statements
  • H302 Harmful if swallowed 吞食有害

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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