(2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-Yl)Nona-2,4,6,8-Tetraenoic Acid (2E,4E,6Z,8E)-3,7-二甲基-9-(2,6,6-三甲基环己-1-烯-1-基)壬-2,4,6,8-四烯酸
CAS 5300-03-8 MFCD00270072
化学结构图
SMILES: CC1=C(/C=C/C(C)=C\C=C\C(C)=C/C(=O)O)C(C)(C)CCC1
化学属性
| Mol. Formula | C20H28O2 |
|---|---|
| Mol. Weight | 300 |
| Melting Point | 178-180° |
| TSCA | No |
别名和识别编码
| Chemical Name | (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-Yl)Nona-2,4,6,8-Tetraenoic Acid |
|---|---|
| CAS Number | 5300-03-8 |
| Synonym | LGD 100057 (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic Acid 9-cis-Tretinoin ALRT 1057 LG 100057 9-CIS-RETINOIC ACID 9-顺式维甲酸 Alitretinoin AGN 192013 9-顺式视黄酸 NSC 659772 LGD 1057 (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid 9-顺式维甲酸 Alitretinoin Panretin |
| MDL Number | MFCD00270072 |
| PubChem Substance ID | 24899373 |
| Merck Number | 14,249 |
| Chemical Name Translation | (2E,4E,6Z,8E)-3,7-二甲基-9-(2,6,6-三甲基环己-1-烯-1-基)壬-2,4,6,8-四烯酸 |
| LabNetwork Molecule ID | LN00193790 |
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信息真实价格透明
资金保障
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品牌质保精细包装
现货库存
一流品牌服务
分类
- Retinoids,
- {SNA} Antitumor Agents, Bioactive Small Molecule Alphabetical Index,
- {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation, Gene Regulation and Expression, Isoprenoids, PPAR and RXR Regulators, Prenols, R, Vitamin A, Vitamins, 抗肿瘤药物, 生化试剂, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 脂类
- {SNA} Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Gene Regulation, Gene Regulation and Expression, Isoprenoids,
产品应用
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相关文献及参考
- [2]. Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64.
- [3]. Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194.
- [4]. V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83.
- [5]. Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5.
- Heyman, R.A., et al.: Cell, 68, 397 (1992),
- Levin, A.A., et al.: Nature, 355, 359 (1992),
- [1]. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40
安全信息
GHS Symbol
- P305+P351+P338
- P308+P313
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H315 Causes skin irritation 会刺激皮肤
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
其他信息
- MOL 文件:5300-03-8.mol
- Sigma Aldrich:5300-03-8(sigmaaldrich)
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