Chloramphenicol Palmitate 氯霉素棕榈酸酯

CAS 530-43-8 MFCD00083597

化学结构图

530-43-8
SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc([N+](=O)[O-])cc1

化学属性

Mol. FormulaC27H42Cl2N2O6
Mol. Weight562
Appearance 白色或微黄色粉状结晶。熔点90℃，极微溶于水（28℃时1.05mg/ml）。溶于甲醇、乙醇、氯仿、乙醚、苯。

别名和识别编码

Chemical NameChloramphenicol Palmitate
MDL NumberMFCD00083597
PubChem Substance ID443382
Beilstein Registry Number2826438
EC Number208-477-9
Synonym (2R,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl hexadecanoate (2R,3R)-2-[(2,2-二氯乙酰基)氨基]-3-羟基-3-(4-硝基苯基)丙基棕榈酸酯 Acetamide, 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, α-palmitate, D-threo- (8CI) CAP-P CAP-palmitate CHLORAMPHENICAL PALMITATE CHLORAMPHENICOL ALPHA-PALMITATE CHLORAMPHENICOL PALMITATE CHLORAMPHENICOLPALMITATE,BP CHLORAMPHENICOLPALMITATE,USP CHLOROAMPHENICOL PALMITATE VETRANAL,250 Chlorambon Chloramphenicol alpha-palmitate Chloramphenicol monopalmitate Chloramphenicol monopalmitate (ester) Chloramphenicol palmitate Chloramphenicol palmitate (ester) ChloramphenicolPalmitateChloramphenicolPalmitateBp Chloromycetin palmitate Chloropal {Pu
CAS Number530-43-8
Chemical Name Translation氯霉素棕榈酸酯
Merck Number13,2087
Wiswesser Line NotationWNR DYQY1OV15&MVYGG
InChIInChI=1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Antibiotics, Bacteriostatic, C, CH, Chemical Structure, Chromatography, Clinical Standards, Others, Principle, Standards for SupelMIP SPE, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Bacteriostatic, C, CH, Chemical Structure, Chromatography, Clinical Standards, Others, Principle, Standards for SupelMIP SPE
  • {SA} Alphabetic,

安全信息

RTECSRT4735000
GHS Symbol
Precautionary statements
  • P203
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P318
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xn
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition Store at RT. 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,248,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   VHAGAS Verhandlungen der Anatomischen Gesellschaft.  (VEB Gustav Fischer
   Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.)  V.1-    1887-
   Volume(issue)/page/year: 71,623,1977

其他信息

  • 可燃性危险特性:热分解排出有毒氮氧化物, 氯化物烟雾
  • 类别:有毒物质
  • 方法一:将α-甲基吡啶及苯加入反应锅，搅拌下加入氯霉素，保持32-37℃，滴加棕榈酰氯。加毕，继续搅拌4h，加至15倍水中，析出粗品。粗品经洗涤、脱色、重结晶，即得无味氯霉素。
  • MOL 文件:530-43-8.mol
  • 毒性分级:中毒
  • 储运特性:库房低温通风干燥
  • 急性毒性:口服-小鼠 LD50: 2640 毫克/公斤
  • Sigma Aldrich:530-43-8(sigmaaldrich)
  • 用途一:抗菌素类药。
  • 上游原料:氧氯化硫 --> 苯 --> 2-甲基吡啶 --> 棕榈酸 --> 氯霉素 --> 棕榈酰氯
  • 灭火剂:水,二氧化碳, 泡沫, 干粉

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CH - C

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