Dichlororibofuranosylbenzimidazole (2R,3R,4S,5R)-2-(5,6-二氯-1H-苯并[d]咪唑-1-基)-5-(羟甲基)四氢呋喃-3,4-二醇

CAS 53-85-0 MFCD00036785

化学结构图

53-85-0
SMILES: OC[C@H]1O[C@@H](n2cnc3cc(Cl)c(Cl)cc32)[C@H](O)[C@@H]1O

化学属性

Mol. FormulaC12H12Cl2N2O4
Mol. Weight319.14
Density1.422
TSCANo
Melting Point 222-224°C
Boiling Point606.2°C at 760 mmHg
Flash Point320.4°C

别名和识别编码

Chemical Name(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-Benzo[D]Imidazol-1-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol
CAS Number53-85-0
Synonym 5,6-Dichlorobenzimidazole riboside {LY} 5,6-Dichlorobenzimidazole riboside DRB Dichlorobenzimidazole Riboside Dichlororibofuranosylbenzimidazole Riboside, Dichlorobenzimidazole {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5,6-Dichlorobenzimidazole riboside {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number250-023-7
Beilstein Registry Number39123
MDL NumberMFCD00036785
PubChem Substance ID5894
Chemical Name Translation(2R,3R,4S,5R)-2-(5,6-二氯-1H-苯并[d]咪唑-1-基)-5-(羟甲基)四氢呋喃-3,4-二醇
Reaxys-RN39123
Wiswesser Line NotationT56 BN DNJ GG HG B- BT5OTJ CQ DQ E1Q
LabNetwork Molecule IDLN01327300
InChIInChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
Canonical SMILESOC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=CC(Cl)=C(Cl)C=C3N=C2)O1
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分类

  • {SNA} Antitumor Agents, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, D-DIF,
  • Nucleotides
  • Inhibitors
  • {SNA} Bioactive Small Molecule Alphabetical Index, D-DIF, DNA-RNA Transcription Regulators, Gene Regulation and Expression, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, 抗肿瘤药物,

产品应用

  • An inhibitor of RNA synthesis (causes premature termination of transcription).

相关文献及参考

  • Braedlye, J. and Sporns, O.: Brain Res., 815, 140 (1999),
  • Ljungman, M., et al.: Oncogene, 18, 583 (1999),

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
RTECSDD7310000
Storage condition -20°C {LY} -20°C <0°C <;0 {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 40 umol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 79,2569,1982

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Insect - not otherwise specified Cells - not
                          otherwise specified
DOSE/DURATION           : 65 umol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   697,213,1982

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Antitumor Agents - Cancer Research
  4. DNA-RNA Transcription Regulators - Antitumor Agents
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. DNA-RNA Transcription Regulators - Gene Regulation and Expression
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Carbohydrate Chemistry - Chemical Biology
  4. Carbohydrate Derivatives 碳水化合物衍生物

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