5-Amino-4,6-dichloropyrimidine 4,6-二氯-5-氨基嘧啶

CAS 5413-85-4 MFCD00006108

化学结构图

5413-85-4
SMILES: Nc1c(Cl)ncnc1Cl

化学属性

Mol. FormulaC4H3Cl2N3
Mol. Weight163.99
Melting Point145-148°C
TSCAYes
Density1.606
Solubility略溶于水
Stability对湿度敏感
Boiling Point267.1°C at 760 mmHg

别名和识别编码

Chemical Name5-Amino-4,6-dichloropyrimidine
CAS Number5413-85-4
Alfabeta NameAMINODICHLOROPYRIMIDINE 546---,
MDL NumberMFCD00006108
Synonym 4,6-Dichloropyrimidin-5-amine {LY} 4,6-Dichloropyrimidin-5-amine {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {}
PubChem Substance ID79434
Beilstein Registry Number126885
EC Number226-503-7
Reaxys-RN126885
Chemical Name Translation4,6-二氯-5-氨基嘧啶
InChIKeyNIGDWBHWHVHOAD-UHFFFAOYSA-N
LabNetwork Molecule IDLN00007841
InChIInChI=1S/C4H3Cl2N3/c5-3-2(7)4(6)9-1-8-3/h1H,7H2
Canonical SMILESClC1=C(N)C(Cl)=NC=N1
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分类

  • Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines
  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines

产品应用

  • 用于在微波加热至 150°C 时,采用三步工艺制造嘧啶并-氧氮杂卓。

相关文献及参考

  • Beilstein:25(3/4)2139
  • Griffith, D., et al.: J. Med. Chem., 52, 234 (2009),
  • Lebsack, A., et al.: Bioorg. Med. Chem. Lett., 19, 40 (2009),
  • Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition -20°C, sealed storage, away from moisture and light {LY} -20°C, sealed storage, away from moisture and light 2-8°C, protect from light Moisture Sensitive {} {LY} -20°C, sealed storage, away from moisture and light {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture

其他信息

  • MSDS 信息:5-Amino-4,6-dichloropyrimidine(5413-85-4).msds
  • Acros Organics:4.6-二氯-5-氨基嘧啶 5-Amino-4,6-dichloropyrimidine, 97%(5413-85-4)
  • TCI Shanghai:5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine,>;98.0%(N)(5413-85-4)
  • 上游原料:乙酸乙酯 --> 硝酸 --> 三氯氧磷 --> 正己烷 --> 三氟乙酸 --> 氯化亚锡 --> N,N-二异丙基乙胺 --> 4,6-二羟基嘧啶
  • 用途一:用于医药中间体的合成
  • F:10-21
  • 微溶于水。
  • 4,6-二氯-5-氨基嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1395 5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine 1G 637元 2014/06/02 A1395 5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine 25G 6530元 2014/06/02 A1395 5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine 5G 1870元
  • MOL 文件:5413-85-4.mol
  • 下游产品:4,5-二氨基嘧啶
  • 敏感性:Moisture Sensitive
  • Sigma Aldrich:5413-85-4(sigmaaldrich)
  • Alfa Aesar:5-氨基-4,6-二氯嘧啶,98+% 5-Amino-4,6-dichloropyrimidine, 98+%(5413-85-4)

系列性分类


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