Palmitoylethanolamide 十六酰胺乙醇

CAS 544-31-0 MFCD00020562

化学结构图

544-31-0
SMILES: CCCCCCCCCCCCCCCC(=O)NCCO

化学属性

Mol. FormulaC18H37NO2
Mol. Weight299.49
SolubilitySoluble in DMSO (20 mM), ethanol (25 mM), chloroform, THF ( at 30 °C), and DMF (~10 mg/ml).
Stability对热敏感
Melting Point97-98 °C
Boiling Point461.5°C at 760 mmHg

别名和识别编码

Chemical NamePalmitoylethanolamide
MDL NumberMFCD00020562
CAS Number544-31-0
Synonym Palmitoylethanolamide {LY} Palmitoylethanolamide {} {LY} Palmitoylethanolamide {} {} {LY} Palmitoylethanolamide {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethanolamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Palmitoylethano
PubChem Substance ID4671
EC Number208-867-9
Chemical Name Translation十六酰胺乙醇
LabNetwork Molecule IDLN00330728
Merck Number6995
InChIInChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
Canonical SMILESCCCCCCCCCCCCCCCC(NCCO)=O
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Cannabinoids, Neurobiology, Neuroscience, PA-PH, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Bioactive Small Molecules,
  • {SNA} Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, P, Pharmacologicals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cannabinoids, Neurobiology, Neuroscience, P-PH, Pharmacologicals, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • An endogenous cannabinoid agonist, FAAH inhibitor, and PPARα agonist

相关文献及参考

  • [1]. Lackovic V, et al. Effect of impulsin treatment of interferon production and antiviral resistance of mice. Arch Immunol Ther Exp (Warsz). 1977;25(5):655-61.

安全信息

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition -20°C {LY} -20°C 0-10°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
RTECSML8950000
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • Palmitoylethanolamide is an endogenous cannabinoid. It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors. It has been found to inhibit FAAH (fatty acid amide hydrolase). Palmitoylethanolamide exhibits anti-nociceptive, anti-inflammatory, anti-convulsant and immunosuppresant activity. Palmitoylethanolamide acts by binding to an unidentified cannabinoid receptor that is similar to CB2. It also acts as a selective activator of the GPR55 receptor. In addition, this compound directly activates PPARα, producing an anti-inflammatory response.

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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