Tibolone 替勃龙
CAS 5630-53-5 MFCD00864178
化学结构图
SMILES: C[C@@]12CC[C@@H]3[C@@H]([C@H]1CC[C@]2(O)C#C)[C@@H](C)CC1CC(=O)CCC=13 |&1:1,4,5,6,9,13|
化学属性
| Mol. Formula | C21H28O2 |
|---|---|
| Mol. Weight | 312.45 |
| Melting Point | 165-169 °C |
| Refractive index | 105 ° (C=0.54, CH2Cl2/Et2O) |
别名和识别编码
| Chemical Name | Tibolone |
|---|---|
| CAS Number | 5630-53-5 |
| Synonym | 17β-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-ene-20-yn-3-one Livial 5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE 7?-Methyl-17?-ethynyl-17?-hydroxy-5(10)-estren-3-one 17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one LIVIAL 替勃龙 (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one 17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one 甲基异炔诺酮 (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one Org OD 14 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7alpha,17alpha)- 19-NORPREGN-5(10)-EN-20-YN-3-ONE,17-HYDROXY-7-METHYL-, (7A,17A)- 7a-Methyl-17a-ethynyl-17-hydroxy-5(10)-estren-3-one 7a-Methyl-5,10-norethindrone 甲基异炔酮 7a-Methyl-17a-ethynyl-17b-hydroxy-5(10)-estren-3-one TIBOLONE LIVIELLA (7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE Liviella (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one 17-羟基-7alpha-甲基-19-去甲孕甾-5(10)-烯-20-炔-3-酮 7a-Methyl-D5,10-norethindrone 17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREGN-5(10)-EN-20-YN-3-ONE (7?,17?)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one 7?-Methyl-5,10-norethindrone 甲异炔诺龙 |
| EC Number | 227-069-1 |
| MDL Number | MFCD00864178 |
| Chemical Name Translation | 替勃龙 |
| Merck Number | 9427 |
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分类
- Androgen, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, Hormones, Progesterone, Steroid Hormones
产品应用
- A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
相关文献及参考
- de Visser, J., et al.: Arzneim.-Forsch., 34, 1010 (1984),
- 1. Groothuis, P.G. et al., Tibolone and metabolites induce prolactin production in human endometrial stromal cells in vitro : evidence for cell-specific metabolism. J. Steroid Biochem. Mol. Biol. 100 , 152-160, (2006)
- 2. Falany, J.L. et al., Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases. J. Steroid Biochem. Mol. Biol. 88 , 383-391, (2004) 摘要
- Merck 14 ,9427
安全信息
GHS Symbol
- P305+P351+P338
- H319 Causes serious eye irritation 严重刺激眼睛
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R51/53
其他信息
- MOL 文件:5630-53-5.mol
- 用途一:雄激素，同化激素类药，治疗妇女更年综合症。
- MSDS 信息:17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one(5630-53-5).msds
- Sigma Aldrich:5630-53-5(sigmaaldrich)
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