O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Phosphorodithioate O,O-二甲基-S-(N-甲基氨基)-2-氧代乙基)二硫代磷酸酯
CAS 60-51-5 MFCD00053676
化学结构图
SMILES: CNC(=O)CSP(=S)(OC)OC
化学属性
| Mol. Formula | C5H12NO3PS2 |
|---|---|
| Mol. Weight | 229 |
| Density | 1.281 |
| Stability | 对光敏感 |
| Boiling Point | 107°C |
| Melting Point | 52-52.5°C |
| Flash Point | 107 °C |
| Solubility | Slightly soluble. 2.5 g/100 mL |
别名和识别编码
| Chemical Name | O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Phosphorodithioate |
|---|---|
| CAS Number | 60-51-5 |
| PubChem Substance ID | 3082 |
| EC Number | 200-480-3 |
| Beilstein Registry Number | 1785339 |
| MDL Number | MFCD00053676 |
| Synonym | dimethoate Cygon 2E Rogor Phosphorodithioic acid, O,O-dimethyl S-( Rogor L FIP Cekuthoate De-fen Sistemin phosphorodithioic acid o,o-dimethyl s-(2-(methylamino)-2-oxoethyl) ester Racusan C Fosfatox R Perfekthion S ROGOR Fosfotox R Fosfotox R 35 S-Methylcarbamoylmethyl O,O-dimethyl phosphorodithioate O,O-Dimethyl S-(N-methylcarbamoylmethyl) dithiophosphate CHAMP Dimethoate {hazard_co Cygon o,o-dimethyl methylcarbamoylmethyl phosphorodithioate Fostion MM { Rogor P BI 58 Sinoratox {hazard_c Aadimethoal 乐果乳油(40%) 乐果乳化剂90-2 Experimental insecticide 12,880 Lurgo O,O-Dimetil-S-(N-metil-carbamoil-metil)-ditiofosf Dithiophosphate de O,O-dimethyle et de S(-N-methylcarbamoyl-methyle) FOSTION MM(R) Daphene O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate Dimat Systemin (pesticide) O,O dimethyl met Rogor 40 CYGON O,O-二甲基-S-(甲基氨基甲酰甲基)二硫代磷酸酯 二硫代磷酸二甲酯(甲基乙酰胺) Phosphorodithioic acid, O,O-dimethyl S-[2-(methylamino)-2 RCRA waste number P044 CL 12880 {uni_ha Phosphorodithio Tara Dimeton {un O,O-DIMETHYL S-(N-METHYLCARBAMOYLMETHYL) PHOSPHORODITHIOATE {h Cygon 400 ENT 24,650 Perfekthion EI-12880 PERFEKTHION(R) Sevigor O,O-Dimethyl |
| Chemical Name Translation | O,O-二甲基-S-(N-甲基氨基)-2-氧代乙基)二硫代磷酸酯 |
| Merck Number | 13,3246 |
| Wiswesser Line Notation | 1OPS&O1&S1VM1 |
| InChI | InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7) |
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分类
- {Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫剂
- {SNA} 2000/60/EC, Acaricides, Alpha sort, Alphabetic, Analytical Standards,
- {SNA} 2000/60/EC, Acaricides, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, D, DID - DIN, EPA, Endocrine Disruptors (Draft), Environmental Standards, European Community: ISO, DIN and DL 152, Insecticides, Method and Regulation Specific, Nematicides, Oeko-Tex Standard 100, Organophorous, Organophosphate, Pesticide Class, P
产品应用
- 校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
相关文献及参考
- Merck: 14,3220
- Short: EINECS
- Short: IV/8A
- Short: III/35A
安全信息
GHS Symbol
- H351 Suspected of causing cancer 怀疑致癌
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
- R45 May cause cancer 可能致癌
- R11 Highly flammable 非常易燃
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R36 Irritating to eyes 刺激眼睛
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S2 Keep out of the reach of children 避免儿童触及；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 176 mg/kg/6W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors REFERENCE : ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 41,311,1973
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 256 mg/kg/4W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors REFERENCE : ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 41,311,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,209,1973
TYPE OF TEST : TD
TYPE OF TEST : LD10 - Lethal Dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 390 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,259,1966
TYPE OF TES
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(6),6,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 30,623,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSER
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 ug/plate REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 24,305,1986
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 10 ppm REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,237,1986
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - hamster DOSE/DURATION : 16 mg/kg REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32-
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 75 ppb/96H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(iss
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 44 umol/L REFERENCE : SOGEBZ Soviet Gene
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Fish - not otherwise specified Lymphocyte DOSE/DURATION : 1 mmol/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8,555,1986
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE
{TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 40 mg/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : BIRUAA Biologische Rundschau. (VEB Gustav Fischer Verlag, Postfach 176, Jena DDR-6900, Ger. Dem. Rep.) V.1- 1963- Volume(issue)/page/year: 13,238,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 120 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issu
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE : 108 mg/kg SEX/DURATION : female 14-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(6),1283,1979
TYPE OF TEST :
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 113 mg/kg SEX/
其他信息
- 下游产品:马拉硫磷 --> 稻丰散 --> 亚胺硫磷 --> 氟硅酸镁 --> 溴化镁 --> 活性氢氧化镁 --> 过氧化镁 --> 腐殖酸镁
- {
- 用途一:属内吸性触杀杀虫、杀螨剂，能防治多种作物上的广谱害虫和螨类，对卫生害虫特别有效
- 方法一:O，O-二甲基二硫代磷酸（简称甲基硫代物）的制备 通常采用P2S5与CH3OH作用，甲醇适当过量，反应温度55～60℃，为强放热反应，操作时要特别注意安全。反应过程较复杂，同时发生一系列副反应。O，O-二甲基二硫代磷酸的收率和含量75%～80%。 采用适当催化剂，在（55±2）℃反应，收率和含量可达90%左右。 O，O-甲基二硫代磷酸盐的制备 O，O-二甲基二硫代磷酸与碳酸钠（铵）或碳酸氢钠在常温下反应，控制终点pH值成盐。 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯的制备 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯由O，O-二甲基二硫代磷酸钠与氯乙酸甲酯作用制得，原料配比为1:1.7，反应温度55℃，若采用连续化生产工艺，预热温度60～70℃，反应温度（80±5）℃。 乐果的合成 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯与一甲胺作用，原料配比为1:(1.2～
- 用途五:乐果是高效广谱具有触杀性和内吸性的杀虫杀螨剂。对多种害虫特别是刺吸口器害虫，具有更高的毒效，杀虫范围广，能防治蚜虫、红蜘蛛、潜叶蝇、蓟马、果实蝇、叶蜂、飞虱、叶蝉、介壳虫。乐果能潜入植物体内保持药效达一星期左右。小鼠口服LD50为156.3mg/kg，经皮LD50为700-1150mg/kg，腹腔注射LD50为184mg/kg。
- {Che
- 用途三
- 用途四:内吸性杀虫、杀螨剂，具有触杀和一定的胃毒作用，无熏蒸
- {Ch
- 急性毒性:口服-大鼠 L
- 图谱信息:乐果(60-51-5)红外图谱(IR1) 乐果(60-51-5)核磁图( 13 CNMR) 乐果(60-51-5)
- 用途四:内吸性杀虫、杀螨剂，具有触杀和一定的胃毒作用，无熏蒸作用。可用于防治多种作物上的刺吸式口器害虫，对蚜虫、螨类及潜叶性害虫高效，用于水稻、棉花、蔬菜、果树等作物。如防治棉蚜、棉红蜘蛛、
- 上游原料:甲醇 --> 甲苯 --> 碳酸钠 --> 碳酸氢钠 --> 一甲胺 --> 氯乙酸 --> 氧化镁 --> 五硫化二磷 --> 乳化剂 --> 二甲基硫 --> 三氯乙烯 --> 硫酸镁 --> 氯乙酸甲酯 --> 二甲基二硫代磷酸酯 --> 硫代磷酸钠 --> 二甲氧基二硫代磷酸基乙酸甲酯 --> 氯乙酰甲胺
- 毒性:纯品对大鼠急性经口LD 50 为500～600mg/kg，工业品为320～380mg/kg（94%～96%）。雄大鼠急性经皮LD 50 为650mg/kg。雄野鸭急性经口LD 50 为15mg/kg，雌鸭为40mg/kg (30mg/kg)。鲤鱼LC 50 为40mg/L（48h)。蜜
- 方法二:工业上生产乐果的方法主要有氯乙酰甲胺法、后胺解法。后一种方法是在氯乙酰甲胺法之后发展起来的，此法副反应少，产品纯度可达90%以上，粗
- 急性毒性:口服-大鼠 LD50: 60 毫克/公斤; 口服-小鼠 LD50: 60 毫克/公斤
- MSDS 信息:乐果(60-51-5).msds
- Sigma Aldrich:60-51-5(sigmaaldrich)
- 灭火剂:砂土、干粉、泡沫
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- 方法一:O，O-二甲基二硫代磷酸（简称甲基硫代物）的制备 通常采用P2S5与CH3OH作用，甲醇适当过量，反应温度55～60℃，为强放热反应，操作时要特别注意安全。反应过程较复杂，同时发生一系列副反应。O，O-二甲基二硫代磷酸的收率和含量75%～80%。 采用适当催化剂，在（55±2）℃反应，收率和含量可达90%左右。 O，O-甲基二硫代磷酸盐的制备 O，O-二甲基二硫代磷酸与碳酸钠（铵）或碳酸氢钠在常温下反应，控制终点pH值成盐。 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯的制备 O，O-二甲基-S-（乙酸甲酯）
- 类别:农药
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