PECAZINE 哌卡嗪

CAS 60-89-9 MFCD00868167

化学结构图

60-89-9
SMILES: CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1

化学属性

Mol. FormulaC19H22N2S
Mol. Weight310.49

别名和识别编码

Chemical NamePhenothiazine, 10-((1-methyl-3-piperidyl)methyl)-
Chemical Name Translation哌卡嗪
Wiswesser Line NotationT C666 BN ISJ B1- CT6NTJ A1
Synonym Meprazine 10-(1-Methyl-3-piperidyl)methyl phenothiazine Pacatal Pakatal MPMP (N-Methyl-3-piperidyl)methylphenothiazine Pecazine P 391 Mepazine Base Paxital Lacumin 10-(1-Methylpiperidyl-3-methyl)phenothiazine Pecatal Pacatal Base Mepazin Mepazine 10H-Phenothiazine, 10-((1-methyl-3-piperazinyl)methyl)- Nothiazine
CAS Number60-89-9
PubChem Substance ID6075
InChIInChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
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相关文献及参考

  • [1]. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.

安全信息

RTECSSP2625000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CANJAE Canadian Anaesthetists' Society Journal.  (Toronto, Ont., Canada)
   V.1-33, 1954-86.  Volume(issue)/page/year: 3,224,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,136,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 4,232,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,489,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECI

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. MALT1  (黏膜相关淋巴瘤转运蛋白1)

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