D-Threonine D-苏氨酸

CAS 632-20-2 MFCD00064269

化学结构图

632-20-2
SMILES: C[C@H](O)[C@@H](N)C(=O)O

化学属性

Mol. FormulaC4H9NO3
Mol. Weight119.12
Melting Point274°C
TSCANo
Density1.307
Solubility可溶
Appearance (大鼠，腹腔)5361 mg/kg。 +12°-+16°(0.5-2.0 mg/ml，5 mol/L HCl)；LD 25 无色结晶状物质；无臭，味甜；溶于水，不溶于乙醇，乙醚和氯仿；分解点为251-253℃；比旋光度[α] D 50 +22°-+26°(0.5-2.0 mg/ml，H2O)，[α]
Refractive index28 ° (C=3, H2O)
Boiling Point345.8°C at 760 mmHg

别名和识别编码

Chemical NameD-Threonine
Synonym D-Threonine {LY} D-Threonine {} {LY} D-Threonine {} {} {LY} D-Threonine {} {} {} {LY} D-Threonine {} {} {} {} {LY} D-Threonine {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-Threonine
MDL NumberMFCD00064269
PubChem Substance ID69435
Beilstein Registry Number4(3)1625
CAS Number632-20-2
EC Number211-171-8
Reaxys-RN1721643
Merck Number9380
Chemical Name TranslationD-苏氨酸
Wiswesser Line NotationQY1&YZVQ -D
InChIKeyAYFVYJQAPQTCCC-STHAYSLISA-N
LabNetwork Molecule IDLN00153227
InChIInChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m0/s1
Canonical SMILESOC([C@@H]([C@@H](O)C)N)=O
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分类

  • {SA} Amino Acid Derivatives, Amino Acids, Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine
  • {SNA} Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine
  • {SNA} Amino Acids, Amino Acids & Derivatives, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine, 生化试剂
  • {Chemicalbook} 生物化学品: 生化试剂: 氨基酸及其衍生物
  • {SNA} Amino Acid Derivatives, Amino Acids, Chemical Biology, Chemical Synthesis, Peptide Chemistry, Threonine, 生化试剂

相关文献及参考

  • Beilstein:4(3)1625
  • For conversion to enantiomerically pure 1,3-butanediol, see: Synth. Commun ., 21, 2295 (1991).
  • [1]. D-Threonine

安全信息

WGK Germany1
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSXO8580000
Signal word Warning
GHS Symbol
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen Store at RT. {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5361 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   64,319,1956

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • 上游原料:氯乙酰氯 --> DL-苏氨酸 --> 酰化氨基酸水解酶
  • 溶于水。
  • 下游产品:L-2-氨基-3-甲基戊酸 --> 头孢拉宗
  • 方法一:以DL-苏氨酸为原料，在碱性条件下与氯乙酰氯反应，减压浓缩后用丙酮萃取，最后由酰化酶I拆分得产品。
  • 图谱信息:D-苏氨酸(632-20-2)红外图谱(IR2) D-苏氨酸(632-20-2)核磁图( 13 CNMR) D-苏氨酸(632-20-2)质谱(MS) D-苏氨酸(632-20-2)红外图谱(IR1)
  • 用途一:用于生化研究。
  • Acros Organics:D-苏氨酸 D-Threonine, 98%(632-20-2)
  • Alfa Aesar:D-苏氨酸,99% D-Threonine, 99%(632-20-2)
  • Sigma Aldrich:632-20-2(sigmaaldrich)
  • 参考质量标准:纸层析合格，比旋光度[α] 25 D +27°-+28°(0.5-2.0 mg/ml，H2O)。
  • TCI Shanghai:D-(+)-苏氨酸 D-(+)-Threonine,>;98.0%(T)(632-20-2)
  • 比旋光度:28 ° (c=6, water)
  • D-苏氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62021531 D-苏氨酸;D-α-氨基-β-羟基丁酸;D-羟基丁氨酸;D-异赤丝藻氨基酸 1g 20元 2011/04/16 T0228 D-(+)-苏氨酸 D-(+)-Threonine 25G 960元 2011/04/16 T0228 D-(+)-苏氨酸 D-(+)-Threonine 500G 8010元
  • MOL 文件:632-20-2.mol

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Threonine - Amino Acid Derivatives
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Threonine - Amino Acid Derivatives
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Amino Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Albumins and Transport Proteins
  4. Albumin
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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