Sulfameter 磺胺对甲氧嘧啶

CAS 651-06-9 MFCD00006067

化学结构图

651-06-9
SMILES: COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1

化学属性

Mol. FormulaC11H12N4O3S
Mol. Weight280
Appearance 白色或微黄色结晶性粉末，无臭，味味苦。熔点214-216℃。极微溶于水、乙醇、乙醚，易溶于碱液。
Melting Point214-216°C
Density1.465

别名和识别编码

Chemical NameSulfameter
CAS Number651-06-9
Synonym I-2586 sulfameter { AHR-857 Juvoxin Kiron 2-Sulfanilamido-5-methoxypyrimidine Ultrax Longasulf LABOTEST-BB LT00451901 Sulfa-5-methyldiazine SULFAMETE 磺胺对甲氧嘧啶 Sulfameter 4-Amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide Sulfamethoxine 磺胺甲氧嘧啶 bayer5400 Sulfamethorine Sulfa-5-methoxypyrimidine 2-sulfanilamido-5-m Benzenesulfonamide, 4-amino-N-(5-methoxy-2-pyridimidinyl)- sulfamethoxydiazine Durenat 5-METHOXYSULFADIAZINE Sulfamethoxydiazine benzenesulfonomide, 4-amino-N-(5-methoxy-2-pyridinyl)- Bayrena Sulfamethoxypyrimidine 2-Sulfanilamido-5-methoxypyrimidin Sulphameter Methoxypyrimal 5-Methoxy-2-sulfanilamidopyrimidine Kirocid 5-Methoxysulfadazine SH 613 磺胺-5-(对)甲氧嘧啶 5-sulfamethoxydiazine sulfamethoxypyrimidine Sulfametin, Sulfametorine 4-amino-N-(5-methoxy-2-pyrdinyl)be Durisan Sulfametoxipirimidine 2-(4-Aminobenzenesulfonamido)-5-methoxypyrimidine Berlicid N(sup 1)-(5-Methoxy-2-pyrimidinyl)sulfanilamide 磺胺5-甲氧嘧啶(磺胺对甲氧嘧啶) Supramid 2-sulfanilamido-5-methoxypyrimidine 5-甲氧基磺胺嘧啶 N1-(5-甲氧基嘧啶-2-基)磺胺 Sulfamethoxydiazine N1-(5-methoxy-2-pyrimidinyl)sulfanilamide Sulfametorine Sulfametoxydiazine; Sulfam Dair 4-amino-n-(5-methoxy-2-pyridimidinyl)-benzenesulfonamid 5-甲氧基磺胺嘧啶 N1-(5-甲氧基嘧啶-2-基)磺胺 2-(对氨基苯磺酰氨基)-5-甲氧基嘧啶 Bayer 5400
MDL NumberMFCD00006067
PubChem Substance ID5326
Beilstein Registry Number621130
EC Number211-480-8
Chemical Name Translation磺胺对甲氧嘧啶
Merck Number13,8999
Wiswesser Line NotationT6N CNJ BMSWR DZ& EO1
LabNetwork Molecule IDLN00194872
InChIInChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bacteriostatic, Biochemicals and Reagents, Chemical Structure, Chromatography, Clinical Standards, Principle, S, SN - SZ, Sulfonamides
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Antibiotics, Antibiotics A to Z, Antibi
  • {Chemicalbook} 饲料添加剂: 抗均促生长剂
  • {SNA} Additional Standards, Analytical Standards, Antibiotics A to Z, Antibiotics N-S, Antibiotics Standards, Bacteriosta

产品应用

  • 磺胺-5-甲氧嘧啶主要用于防治溶血性链球菌、肺炎球菌及脑膜炎球菌引起的感染。治疗球虫病。泌尿道及呼吸道感染等疾病。

相关文献及参考

  • Horstmann, et al.: Arzneim.-Forsch., 11, 682 (1961),
  • Hecht, G., et al.: Arzneim.-Forsch., 11, 695 (1961),
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany2
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSWP0525000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 储存温度2-8℃ 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   12ZWAM "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F.
   Hawking, eds.  Academic Press, New York, 1964  Volume(issue)/page/year:
   2,249,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,695,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperito

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,695,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   12ZWAM "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F.
   Hawking, eds.  Academic Press, New York, 1964  Volume(issue)/page/year:
   2,249,1964

TYPE O

其他信息

  • 上游原料:磺胺脒
  • 方法二:由乙醛经缩合、氯化、醚化、环合制得该品。
  • 方法一:由乙醛经缩合、氯化、醚化，再与磺胺脒环合制得。
  • 用途四:主要用于防治溶血性链球菌、肺炎球菌及脑膜炎球菌引起的感染。治疗球虫病。泌尿道及呼吸道感染等疾病。
  • 用途三:主要用于防治溶血性链球菌、肺炎球菌及脑膜炎球菌引起的感染。治疗球虫病、泌尿道及呼吸道感染等疾病。
  • 几乎不溶于水、醚或乙醇，微溶于酸，易溶于碱。无臭，味苦。
  • Sigma Aldrich:651-06-9(sigmaaldrich)
  • 用途一:对革兰阳性和阴性菌如化脓性链球菌、沙门氏菌和肺炎杆菌等均有良好的抗菌作用
  • 参考质量标准:参见《中国兽药典》1990年版 含量(干基)/% ≥99.0 氯化物(Cl - )/% ≤0.01 灼烧残渣/% ≤0.1 重金属/% ≤0.0015
  • MSDS 信息:Sulfameter(651-06-9).msds
  • 图谱信息:磺胺对甲氧嘧啶(651-06-9)核磁图( 1 HNMR) 磺胺对甲氧嘧啶(651-06-9)红外图谱(IR1) 磺胺对甲氧嘧啶(651-06-9)核磁图( 13 CNMR) 磺胺对甲氧嘧啶(651-06-9)质谱(MS) 磺胺对甲氧嘧啶(651-06-9)红外图谱(IR2)
  • 用途二:作为抗菌剂，对溶血性链球菌、肺炎球菌、大肠杆菌均有效。主要用于治疗尿路感染、呼吸道感染和球虫病等。
  • MOL 文件:651-06-9.mol

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Chemical Structure Class - Antibiotics
  4. Sulfonamides - Chemical Structure Class
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. S - Alphabetic
  5. SN - SZ - S

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