(S)-(6-Methoxyquinolin-4-Yl)((1S,2R,4S,5R)-5-Vinylquinuclidin-2-Yl)Methanol Sulfate Hydrate (S)-(6-甲氧基喹啉-4-基)((1S,2R,4S,5R)-5-乙烯基quinuclidin-2-基)甲醇硫酸盐水合物

CAS 6591-63-5 MFCD00149346

化学结构图

6591-63-5
SMILES: C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12.C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12.O.O.O=S(=O)(O)O

化学属性

Mol. FormulaC40H48N4O4.H2SO4.2H2O
Mol. Weight782.95 g/mol
Melting Point212-214°C
TSCAYes
Refractive index275 ° (C=2, 0.1mol/L HCl)
Stability对光敏感

别名和识别编码

Chemical Name(S)-(6-Methoxyquinolin-4-Yl)((1S,2R,4S,5R)-5-Vinylquinuclidin-2-Yl)Methanol Sulfate Hydrate
MDL NumberMFCD00149346
CAS Number6591-63-5
PubChem Substance ID656862
EC Number200-046-3
Synonym (S)-[(4S,5R,7R)-5-Ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol sulfate dihydrate 6-methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanolhemisulfatehyd QUINIDINE SULFATE QUINIDINE SULFATE 99+% QUINIDINE SULFATE DIHYDRATE QUINIDINE SULFATE SALT DIHYDRATE QUINIDINE SULPHATE DIHYDRATE QUINIDINESULFATE,DIHYDRATE,USP Quinidine dihydrate sulfate salt Quinidine Sulfate Dihydrate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Merck Number14,8060
Chemical Name Translation(S)-(6-甲氧基喹啉-4-基)((1S,2R,4S,5R)-5-乙烯基quinuclidin-2-基)甲醇硫酸盐水合物
LabNetwork Molecule IDLN00242978
InChIInChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19+,20-;;;/m00.../s1
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels,
  • {SNA} Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Fluorination Ready Pharma-Developed Compounds, Ion Channels, Monovalent Ion Channels, Other Sodium Channel Modulators, Q, Sodium Channel Modulators,
  • {SNA} Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Fluorination Ready Pharma-Developed Compounds, Ion Channels,
  • {SNA} Analytical

产品应用

  • Class IA型抗心律失常药，钾通道阻障剂。

相关文献及参考

  • [2]. Tsuruo T, et al. Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.Cancer Res. 1984 Oct;44(10):4303-7.
  • Merck: 14,8060
  • Merck: 14,8060 Beilstein: 23,507
  • [1]. David E. Moody, et al. Quinidine Inhibits In Vivo Metabolism of Amphetamine in Rats: Impact upon Correlation between GCIMS and Immunoassay Findings in Rat Urine. ournal of Analytical Toxicology, Vol. 14, September/October 1990
  • [1]. David E. Moody, et al. Quinidine Inhibits In Vivo Metabolism of Amphetamine in Rats: Impact upon Correlation between GCIMS and Immunoassay Findings in Rat Urine. ournal of Analytical Toxicology, Vol. 14, September/October 1990
  • [2]. Tsuruo T, et al. Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.Cancer Res. 1984 Oct;44(10):4303-7.

安全信息

RTECSVA5605000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Storage condition Light Sensitive 避光保存

其他信息

  • 用途一:Class IA型抗心律失常药，钾通道阻障剂。
  • TCI Shanghai:奎尼定硫酸盐 Quinidine Sulfate Dihydrate,>;98.0%(T)(6591-63-5)
  • 无臭，味极苦，遇光颜色渐变暗。
  • Sigma Aldrich:6591-63-5(sigmaaldrich)
  • 硫酸奎尼丁二水合物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 61003980 硫酸奎尼丁 5g 470元
  • 图谱信息:硫酸奎尼丁二水合物(6591-63-5)红外图谱(IR2) 硫酸奎尼丁二水合物(6591-63-5)核磁图( 1 HNMR) 硫酸奎尼丁二水合物(6591-63-5)红外图谱(IR1) 硫酸奎尼丁二水合物(6591-63-5)核磁图( 13 CNMR)
  • MOL 文件:6591-63-5.mol
  • 外观性质:无臭，味极苦，遇光颜色渐变暗。熔点：213 °C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Sodium Channel Modulators - Monovalent Ion Channels
  8. Other Sodium Channel Modulators - Sodium Channel Modulators
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Sodium Channel Modulators - Monovalent Ion Channels
  8. Other Sodium Channel Modulators - Sodium Channel Modulators
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Optical Resolution
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Alkaloids
  1. Medical Research Areas
  2. Metabolism
  3. Cytochrome P450  (细胞色素P450)

相关产品推荐