Hydroxyprogesterone 羟孕酮

CAS 68-96-2 MFCD00003659

化学结构图

68-96-2
SMILES: CC(=O)[C@@H]1CC[C@@H]2[C@H]3CCC4=CC(=O)CC(O)[C@@]4(C)[C@@H]3CC[C@]21C |&1:3,6,7,17,19,22|

化学属性

Mol. FormulaC21H30O3
Mol. Weight330
Melting Point217.0-221.0
Refractive index90 ° (C=1, CHCl3)
SolubilitySoluble in water (partly), chloroform, methanol, and Dichloromethane.

别名和识别编码

Chemical NameHydroxyprogesterone
Synonym 17-HYDROXYPROGESTERONE 17-Hydroxypregn-4-en-3,20-dione 17ALPHA-HYDROXYPROGESTERONE Gestageno gador 17A-HYDROXYPROGESTERONE 17-Hydroxyprogesterone 4-pregnen-17a-ol-3,20-dione prodix 17α-Hydroxy-4-pregnene-3,20-dione gestagenogador 孕甾-4-烯-17α-醇-3,20-二酮 (17S)-17-Hydroxypregn-4-ene-3,20-dione 17a-hydroxypregn-4-ene-3,20-dione 17α-羟基黄体酮 羟基黄体酮 17-Hydroxy-4-pregnene-3,20-dione 17Α-羟基孕烯二酮 17-羟基妊娠素 17α-羟基孕甾-4-烯-3,20-二酮 17α-羟基黄体酮 4-PREGNEN-17ALPHA-OL-3,20-DIONE 羟孕酮 17alpha-Hydoxyprogesterone 17β-Hydroxy-17-acetylandrosta-4-ene-3-one {ha
MDL NumberMFCD00003659
PubChem Substance ID24278469
Beilstein Registry Number3218109
CAS Number68-96-2
EC Number200-699-4
Chemical Name Translation羟孕酮
Merck Number4839
Reaxys-RN3218109
InChIKeyDBPWSSGDRRHUNT-SJFWLOONSA-N
LabNetwork Molecule IDLN00197016
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments, Chromatography, Clinical Standards, H, HU - HZ, Hormones, Neats and Solutions, Pharma, 生物活性小分子, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
  • {SNA} Additional Standards, Analytical Standards,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, H, Hormones, Progesterone, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学,

产品应用

  • 一种长效孕激素

相关文献及参考

  • Linder, N., et al. Arch. Dis. Child Fetal Neonatal Ed. 81 , 175, (1999)
  • Merck 14 ,4839
  • Beil. 8 ,IV,2189

安全信息

RTECSTU5060000
GHS Symbol
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Hazard Codes T
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ACEDAB Acta Endocrinologica, Supplementum (Copenhagen).  (Periodica,
   Skolegade 12 E, DK-2500 Valby, Denmark)  No.1-    1948-
   Volume(issue)/page/year: 28,18,1956

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 65 mg/kg
SEX/DURATION            : female 8-32 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 26,151,1960

其他信息

  • 上游原料:薯蓣皂素
  • 下游产品:6-亚甲基孕甾-4-烯-17Α-醇-3,20-二酮-17-醋酸酯 --> 醋酸甲地孕酮 --> 17-羟基孕甾-4-烯-3,20-二酮-17-醋酸酯 --> 17Α-乙酰氧基-6-二溴亚甲基孕甾-4-烯-3,20-二酮
  • 用途二:氢化可的松、甲地孕酮、己酸孕酮的中间体。
  • 方法一:可用薯蓣皂素经开环、乙酰化、氧化、水解、环氧化、氧化、加成、催化氢化等步反应制得。
  • 用途一:用作甾体激素药中间体
  • MOL 文件:604-09-1.mol
  • MOL 文件:68-96-2.mol
  • Sigma Aldrich:68-96-2(sigmaaldrich)

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Market Segments - Analytical Standards
  4. Standards for Pharma Clinical Forensic & Veterinary Analysis - Market Segments
  5. Neats and Solutions - Standards for Pharma Clinical Forensic & Veterinary Analysis
  6. Hormones - Neats and Solutions
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Progesterone - Steroid Hormones
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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