N-(3-Chloropropyl)Morpholine N-(3-氯丙基)吗啉

CAS 7357-67-7 MFCD00039714

化学结构图

7357-67-7
SMILES: ClCCCN1CCOCC1

化学属性

Mol. FormulaC7H14ClNO
Mol. Weight163.65
Boiling Point227.1°C at 760 mmHg
Refractive index1.4720 to 1.4760
Solubility溶于氯仿。
Stability对空气及热敏感

别名和识别编码

Chemical NameN-(3-Chloropropyl)Morpholine
CAS Number7357-67-7
Alfabeta NameCHLOROPROPYLMORPHOLINE 43()----
MDL NumberMFCD00039714
Chemical Name TranslationN-(3-氯丙基)吗啉
Reaxys-RN105107
Synonym 4-(3-Chloropropyl)morpholine {LY} 4-(3-Chloropropyl)morpholine {} {LY} 4-(3-Chloropropyl)morpholine {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(3-Chloropropyl)morpholine {} {} {} {} {} {} {} {} {} {} {} {}
EC Number461-510-0
PubChem Substance ID95834
InChIKeyPIAZYBLGBSMNLX-UHFFFAOYSA-N
LabNetwork Molecule IDLN00004308
InChIInChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
Canonical SMILESClCCCN1CCOCC1
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产品应用

  • 4-(3-氯丙基)吗啉是合成吉非替尼的一种中间体。

安全信息

Warnings IRRITANT
RTECSQE0488000
GHS Symbol
Signal word
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P333+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen 0-10°C {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 104 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 33,169,1976

系列性分类


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