Thyroxine

CAS 7488-70-2 MFCD N/A

化学结构图

7488-70-2
SMILES: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O

化学属性

Mol. Weight776.87
Mol. FormulaC15H11I4NO4

别名和识别编码

Synonym THX T4 (hormone) L-3,5,3'5'-Tetraiodothyronine T4 (pharmaceutical) (-)-Thyroxine Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo- β-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine Thyrax L-T4 Thyroxine iodine O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine L-Thyroxine 3,3',5,5'-Tetraiodo-L-thyronine DL-thyroxin 3,5,3',5'-Tetraiodothyronine 3,3',5,5'-Tetraiodthyronin 3,3',5,5'-Tetrajod-L-thyronin Thyreoideum Thyroxinal Thyratabs L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo- 3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine Levothyroxine levothyroxine (INNM) Thyroxine, L-
Wiswesser Line NotationQVYZ1R CI EI DOR DQ CI EI
Chemical NameThyroxine
CAS Number7488-70-2
PubChem Substance ID853
InChIInChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; carboxylic acid; alcohol; ether; chiral; 1fragment

相关文献及参考

  • Short: III/20c Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei Zr ... Bi. Diagrams, Structure formulas, Indexes Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20c Year: 1989 Keyword: NQR ISBN: 3-540-18490-2 ISBN: 978-3-540-18490-4 Internet Resource: DOI:10.1007/b35374 RefComment: 562 figs., IX,802 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

RTECSXP3582400 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 30 ug/kg/3W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   292,1185,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 42 ug/kg/1W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NEURAI Neurology.  (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1951-  Volume(issue)/page/year: 35,1792,1985

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 3125 ug/kg
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 72,942,1971

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 250 ug/kg/7D
REFERENCE :
   RRENAR Revue Roumaine d'Endocrinologie.  (Bucharest, Romania)  V.1-11,
   1964-74.  For publisher information, see RRENDU.  Volume(issue)/page/year:
   10,149,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 9-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   AFPEAM Archives Francaises de Pediatrie.  (Doin Editeurs, 8, Place de
   l'Odeon, F-75006 Paris, France) V.1-    1942-  Volume(issue)/page/year:
   11,168,1954

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 19310 ug/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 99,97,1954

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 500 ug/kg
SEX/DURATION            : female 25-26 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   DPTHDL Developmental Pharmacology and Therapeutics.  (S. Karger Pub., Inc.,
   79 Fifth Ave., New York, NY 10003)  V.1-    1980-  Volume(issue)/page/year:
   9,115,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 27500 ug/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   BSOFAK Bulletin d

系列性分类

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