Methodichlorophen

CAS 7761-45-7 MFCD00866407

化学结构图

7761-45-7
SMILES: CC1=NC(N)=NC(N)=C1C1C=C(Cl)C(Cl)=CC=1

化学属性

Mol. FormulaC₁₁H₁₀Cl₂N₄
Mol. Weight269.13
Melting Point>234°C (dec.)
Density1.447
Boiling Point

别名和识别编码

Chemical NameMethodichlorophen
CAS Number7761-45-7
Synonym 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine 2,4-Diamino-5-(3,4- 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl- 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine BW 50-197 BW-197U DDMP Methodichlorophen Metoprine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation
Wiswesser Line NotationT6N CNJ BZ DZ ER CG DG& F1
Beilstein Registry Number0223622
MDL Number
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分类

  • Heterocycles
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A 2,4-Diaminopyrimidine derivative as antimalarial agent.

相关文献及参考

  • Andersson, K.J.I., et al.: Nature, 143, 720 (1939),
  • Cecil, R., et al.: Biochem.J., et al.: 43, 592 (1948),

安全信息

RTECSUV8180000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   14XBAV "International Congress of Chemotherapy, Proceedings of the 3rd
   Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep.
   Ger., Georg Thieme Verlag, 1964  Volume(issue)/page/year: -,367,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 60,547,1976

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Human
DOSE/DURATION           : 2800 ug/kg
REFERENCE :
   RBBIAL Revista Brasileira de Biologia.  Brazilian Review of Biology.
   (Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro,
   Brazil)  V.1-    1941-  Volume(issue)/page/year: 25,145,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 ug/kg
SEX/DURATION            : female 6-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 87,571,1954

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 8-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 87,571,1954

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 87,571,1954

Storage condition 4

系列性分类

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