2-(4-Chlorophenyl)-3-Methyl-1,3-Thiazinan-4-One 1,1-Dioxide 2-(4-氯苯基)-3-甲基-4H-1,3-四氢噻嗪-4-酮-1,1-二氧化物

CAS 80-77-3 MFCD00143951

化学结构图

80-77-3
SMILES: CN1C(C2C=CC(Cl)=CC=2)S(=O)(=O)CCC1=O

化学属性

Mol. FormulaC11H12ClNO3S
Mol. Weight273.73
Melting Point113.0 to 116.0 deg-C
SolubilityDMSO 55 mg/mL Water <1 mg/mL Ethanol 26 mg/mL

别名和识别编码

Chemical Name2-(4-Chlorophenyl)-3-Methyl-1,3-Thiazinan-4-One 1,1-Dioxide
Synonym 2-(4-Chlorophenyl)-3-methyl-4-metathiazanone-1,1-dioxide Mio-sed Tanafol Clormetazon 氯美扎酮 Miorilax Banabin Phenarol Clormetazanone Chlormethazanone 2-(4-Chlorophenyl)-3-methyl-4-methathiazanone-1,1-dioxide Dichloromethazanone 2-(p-Chlorophenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide Rilansyl Rilassol 2-(p-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide 4H-1,3-Thiazin-4-one, tetrahydro-2-(p-chlorophenyl)-3-methyl-, Banabin-sintyal Muskel Chlormethazone Lobak Fenarol Clorilax Rexan Chlormezanone Muskel-trancopal Rilax Bisina Rilaquil
MDL NumberMFCD00143951
CAS Number80-77-3
EC Number201-307-4
Reaxys-RN23033
PubChem Substance ID87566243
Merck Number2106
Chemical Name Translation2-(4-氯苯基)-3-甲基-4H-1,3-四氢噻嗪-4-酮-1,1-二氧化物
Wiswesser Line NotationT6VN DSWTJ B1 CR DG
LabNetwork Molecule IDLN01342350
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安全信息

RTECSXJ1050000
Signal word
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
GHS Symbol
Storage condition 储存温度-20°C 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20 gm/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - emphysema
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   HOCHE8 Hochudoku.  (Nippon Hochudoku Gakkai, c/o Kyushu Daigaku Igakubu
   Hoigaku Kyoshitsu, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan)  V.8-
   1990-  Volume(iss

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   286,845,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 157 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - ataxia
   Behavioral - coma
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   292,732,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 370 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,242,1967

系列性分类

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