15,16-Dihydro-11-methylcyclopenta(a)phenanthren-17-one

CAS 892-17-1 MFCD00869460

化学结构图

892-17-1
SMILES: Cc1cc2c(c3ccc4ccccc4c13)CCC2=O

化学属性

Mol. FormulaC18H14O
Mol. Weight246.32

别名和识别编码

Chemical Name15,16-Dihydro-11-methylcyclopenta(a)phenanthren-17-one
Wiswesser Line NotationL E5 B666 FVT&&&J N1
Synonym 11-CH3-cpp-17-one 11-Methyl-15,16-dihydro-17-oxocyclopenta(a)phenanthrene 11-Methyl-15,16-dihydro-17H-cyclopenta(a)phenanthren-17-one 11-methyl-15,16-dihydrocyclopenta(a)phenanthren-17-one 15,16-Dihydro-11-methyl-17H-cyclopenta(a)phenanthren-17-one 15,16-Dihydro-11-methylcyclopenta(a)phenanthren-17-one 15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one DH-11-MCPPO
Beilstein Registry Number2280058
CAS Number892-17-1
InChIKeySKCVVXWCDKAJTI-UHFFFAOYSA-N
PubChem Substance ID3034752
InChIInChI=1S/C18H14O/c1-11-10-16-14(8-9-17(16)19)15-7-6-12-4-2-3-5-13(12)18(11)15/h2-7,10H,8-9H2,1H3
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   PEXTAR Progress in Experimental Tumor Research.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1960-  Volume(issue)/page/year:
   11,69,1969

{

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg/50W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   38,148,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 210,1281,1966

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 46 mg/kg/19W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6

RTECSGY5775000 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,11,1984

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 10 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,2261,1983

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Intramuscular
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 120 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,3967,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,882,1980

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 nmol/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 13,329,1992

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th

系列性分类

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