2-Propen-1-one, 2-[(dimethylamino)methyl]-1-(2,4-dimethylphenyl)- 化合物L-Asparaginase

CAS 9015-68-3 MFCD00130565

化学结构图

9015-68-3
SMILES:

化学属性

Mol. Weight1
Mol. FormulaH2

别名和识别编码

Synonym Asparaginase from Escherichia coli L-Asparagine Amidohydrolase Colaspase MK-965 E. C. 3.5.1.1 l-Asparaginase X L-Asparaginasi Asparaginase L-Asparagine amidohydrolase Kidrolase Elspar L-Asnase Crasnitin Leucogen Leunase NSC-109229 Re 82-Tad-15
MDL NumberMFCD00130565
CAS Number9015-68-3
EC Number232-765-3
Chemical NameL-Asparaginase
Chemical Name Translation化合物L-Asparaginase
PubChem Substance ID436058
InChIInChI=1S/C14H19NO/c1-10-6-7-13(11(2)8-10)14(16)12(3)9-15(4)5/h6-8H,3,9H2,1-2,4-5H3
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分类

  • {SNA} 3.5.x.x Acting on C-N other than peptides, 3.x.x.x Hydrolases, Amino Acid Metabolism, Biochemicals and Reagents, Enzyme Class Index, General Metabolic Enzymes, 代谢组学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} 3.5.x.x Acting on C
  • {SNA} 3.5.x.x Acting on C-N other than peptides, 3.x.x.x Hydrolases, Amino Acid Metabolism, Enzyme Class Index, General Metabolic Enzymes, 代谢组学, 生化试剂, 细胞生物学, 酶、抑制剂和底物
  • 3.5.x.x Acting on C-N other than peptides, 3.x.x.x Hydrolases, Amino Acid Metabolism, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, General Meta

相关文献及参考

  • Michel Duval, Stefan Suciu, Comparison of Escherichia coli–asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer—Children's Leukemia Group phase 3 trial Blood 99 , 2734-2739, (2002)
  • Amy L. Swain, Mariusz Jaskolski, Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy Proc. Natl. Acad. Sci. U. S. A. 90 , 1474-1478, (1993)
  • Mario Sanches, Structural comparison of Escherichia coli L-asparaginase in two monoclinic space groups, March 2003;59(3):416 Acta Crystallogr. D , (2003)
  • Merck 14 ,836

安全信息

RTECSCI9000000
GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Warning
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Hazard Codes Xn
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R42/43 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 iu/kg/4D
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - leukemia
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 47,418,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8204 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Re

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 334 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,271,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2273 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,271,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 11662 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 200 iu/kg
SEX/DURATION            : female 8-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 218,1164,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 31815 ug/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFEC

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15911 ug/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,271,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 47726 ug/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,271,1969

系列性分类

  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. General Metabolic Enzymes - Metabolomics
  4. Amino Acid Metabolism - General Metabolic Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 3.x.x.x Hydrolases - Enzyme Class Index
  6. 3.5.x.x Acting on C-N other than peptides - 3.x.x.x Hydrolases

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