8-Amino-6-Methoxyquinoline 8-氨基-6-甲氧基喹啉
CAS 90-52-8 MFCD00672902
化学结构图
SMILES: COc1cc(N)c2ncccc2c1
化学属性
| Mol. Formula | C10H10N2O |
|---|---|
| Mol. Weight | 174.20 |
| Appearance | 白色结晶。熔点41℃，沸点137-138℃（133Pa）。 |
| Melting Point | 41°C |
| Boiling Point | 361.8±27.0°C at 760 mmHg |
别名和识别编码
| Chemical Name | 8-Amino-6-Methoxyquinoline |
|---|---|
| Alfabeta Name | METHOXYQUINOLINAMINE 68--- |
| MDL Number | MFCD00672902 |
| Chemical Name Translation | 8-氨基-6-甲氧基喹啉 |
| Synonym | 8-Amino-6-methoxyquinoline {LY} 8-Amino-6-methoxyquinoline {} {LY} 8-Amino-6-methoxyquinoline {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} { |
| CAS Number | 90-52-8 |
| EC Number | 202-001-3 |
| Wiswesser Line Notation | T66 BNJ HO1 JZ |
| Beilstein Registry Number | 0133397 |
| InChIKey | YGGTVPCTAKYCSQ-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00159054 |
| PubChem Substance ID | 7023 |
| InChI | InChI=1S/C10H10N2O/c1-13-8-5-7-3-2-4-12-10(7)9(11)6-8/h2-6H,11H2,1H3 |
| Canonical SMILES | COC1=CC(N)=C2N=CC=CC2=C1 |
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安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
GHS Symbol
其他信息
- 用途一:抗疟类药物磷酸伯氨喹啉、戊喹、扑疟喹的中间体。
- 方法一:6-甲氧基-8-硝基喹啉在盐酸介质中用铁粉还原、再用液碱中和而得。将盐酸投入搪玻璃反应锅，升温到50℃，投入6-甲氧基-8-硝基喹啉、铁粉。在65-70℃于3.5h内全部加完，保温2h，冷却，过滤得粗品8-氨基-6-甲氧基喹啉盐酸盐。再经盐析精制，用稀碱中和至pH7，析出8-氨基-6-甲氧基喹啉，过滤得粗品，用甲苯精制，得8-氨基-6-甲氧基喹啉。收率65%。产品规格：含量≥65%。原料消耗定额：6-甲氧基-8-硝基喹啉（94%）1765kg/t、盐酸（37%）10479kg/t、铁屑（工业品）2519kg/t。
- MOL 文件:90-52-8.mol
- 上游原料:乙醇 --> 氢氧化钠 --> 盐酸 --> 乙酸乙酯 --> 硫酸 --> 石油醚 --> 三氯甲烷 --> 氨 --> 氯化亚锡 --> 甘油 --> 硝基苯 --> 搪玻璃反应锅 --> 铁屑 --> 冰染重氮组分 1 --> 6-甲氧基-8-硝基喹啉 --> 奎啉盐酸盐
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