Chlorpropamide 1-(4-氯苯磺酰基)-3-丙脲
CAS 94-20-2 MFCD00079004
化学结构图
SMILES: CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1
化学属性
| Mol. Formula | C10H13ClN2O3S |
|---|---|
| Mol. Weight | 277 |
| TSCA | No |
| Appearance | 白色结晶性粉末。熔点127-129℃。易溶于氯仿和丙酮，略溶于乙醚、苯、在pH为6的水中溶解度为2.2mg/ml，在pH7.3的水中不溶。无臭，无味。 |
| Melting Point | 127-130 |
| Solubility | DMSO 55 mg/mL Water <1 mg/mL Ethanol 55 mg/mL |
别名和识别编码
| Chemical Name | Chlorpropamide |
|---|---|
| CAS Number | 94-20-2 |
| Synonym | NCI-C01752 N-Propyl-N'-(p-chlorobenzenesulfonyl)urea { 特泌胰 4-Chloro-N-[(propylamino)-carbonyl]benzenesulfonamide {hazar Diabeneza Chloronase Meldian Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]- ######## {Chemicalb 4-Chloro-4-((propylamino)carbonyl)benzenesulfonamide N-(p-Chlorobenzenesulfonyl)-N'-propylurea 1-p-Chlorophenyl-3-(propylsulfonyl)urea CHLOROPROPAMIDE N’-丙基-N’-对氯苯磺酰基脲 对氯苯磺酰丙脲 1-(p-Chlorobenzenesulfonyl)-3-propylurea 1-Propyl-3-(p-chlorobenzenesulfonyl)urea Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)- Mellinese 1-(4-CHLOROPHENYLSULFONYL)-3-PROPYLUREA Diabaril 1-[P-CHLOROBENZENESULFONYL]-3-PROPYLUREA 氯磺丙脲 1-((p-chloropenyl)sulfonyl)-3-propyl-ure Prodiaben P 607 {h 4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide Glisema 4-chloro-n-[(propylamino)carbonyl]-benzenesulfonamid 4-chloro-n-((propylamino)carbonyl)-benzenesulfonamid Diabenese U-3818 N-Propyl-N'-p-chlorphenylsulfonylcarbamide Diabexan 1-(4-Chlorobenzenesulfonyl)-3-n-propylurea 1-(p-Chlorophen 4-Chloro-N-[(propylamino)carbonyl]benzene-sul-fonamide Diabinese CHLORPROPAMIDE Diabenal Adiaben 1-(4-Chlorophenylsulfonyl)-3-propylurea Diabet-pages 特泌胰;对氯苯磺酰丙脲;1-(4-氯苯磺酰基)-3-丙脲;N'-丙基-N'-对氯苯磺酰基脲 1- Diabetoral 1-((p-chlorophenyl)sulfonyl)-3-propyl-ure Chlorpropamide bioglumin Chloropropamide |
| MDL Number | MFCD00079004 |
| PubChem Substance ID | 2727 |
| EC Number | 202-314-5 |
| Merck Number | 2186 |
| Reaxys-RN | 2218363 |
| Chemical Name Translation | 1-(4-氯苯磺酰基)-3-丙脲 |
| Beilstein Registry Number | 2218363 |
| Wiswesser Line Notation | GR DSWMVM3 |
| LabNetwork Molecule ID | LN00196005 |
| InChI | InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14) |
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分类
- {SNA} Analytical S
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards,
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, C, CH, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, C, C-CH, CH, Cell Biology
- Sulfur & Selenium Compounds
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
- Pharmaceuticals
- {SNA} Additional Standards,
- {SNA} Analytical Stan
产品应用
- ########
相关文献及参考
- Turner, R.C. et al.: Diabetes, 27, 241 (1978); Grinnell, E.H. et al.: Am. J. Med. Sci., 253, 312 (1967); Taylor, J.A.: Clin. Pharmacol. Therap., 13, 710 (1972);
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H332 Harmful if inhaled 吸入有害
- H351 Suspected of causing cancer 怀疑致癌
- H312 Harmful in contact with skin 皮肤接触有害
- H312+H332
- H303 May be harmfully swallowed 吞食可能有害
- S22 Do not breathe dust 不要吸入粉尘；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TD
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSER
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 25 mg/kg/5D-I TOXIC EFFECTS : Blood - other hemolysis with or without anemia REFERENCE : DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 18,981,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 409 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 83 mg/kg/25D-I TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from large intestine Liver - jaundice, cholestatic REFERENCE : AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954- Volume(issue)/page/year: 80,381,1985
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 177 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,349,1980
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Fibroblast DOSE/DURATION : 2 gm/L REFERENCE : ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 2400 mg/L REFERENCE : GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 250 mg/L/30H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 56,215,1977
TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - hamster DOSE/DURATION : 7100 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amste
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 166 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/pag
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE : 1358 mg/kg SEX/DURATION : female 1-26 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,187,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 884 mg/kg SEX/DURATION : female 1-35 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year: 49,283,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1 gm/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : PROEAS Problemy Endokrinologii. Problems of Endocrinology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-6, 1936-41; 13- 1967- Volume(issue)/page/year: 14,89,1968
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE : 180 mg/kg SEX/DURATION : female 26-39 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive
其他信息
- Sigma Aldrich:94-20-2(sigmaaldrich)
- 上游原料:丁酰胺 --> 4-氯苯磺酰胺 --> 异氰酸丙酯
- MOL 文件:94-20-2.mol
- 图谱信息:氯磺丙脲(94-20-2)红外图谱(IR1) 氯磺丙脲(94-20-2)核磁图( 1 HNMR) 氯磺丙脲(94-20-2)核磁图( 13 CNMR) 氯磺丙脲(94-20-2)质谱(MS) 氯磺丙脲(94-20-2)红外图谱(IR2)
- 氯磺丙脲价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1220 1-(4-氯苯磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea 500G 4600元 2014/06/02 C1220 1-(4-氯苯磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea 25G 623元
- TCI Shanghai:1-(4-氯苯基磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea,>;99.0%(T)(94-20-2)
- 方法一:由对氯苯磺酰胺与丁酰胺反应而得对氯苯磺酰丙脲钠盐。再用盐酸酸化、精制而得成品。另一种方法是以对氯苯磺酰胺、异氰酸丙酯、三乙胺为原料。
- 用途一:磺脲类口服降血糖药。作用强而持久，主要选择性地作用于胰岛-β-细胞，促进胰岛的分泌，使血糖降低。用于糖尿病。氯磺丙脲具有比较大的副作用，所以该药的使用量有逐年减少的趋势。
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