Pyridine-2-Aldoxime Methiodide 吡啶-2-乙醛肟甲碘化物

CAS 94-63-3 MFCD00011982

化学结构图

94-63-3
SMILES: C[n+]1ccccc1C=NO.[I-]

化学属性

Mol. FormulaC7H11IN2O
Mol. Weight266.08
Melting Point220 °C (dec.)(lit.)
TSCANo
Appearance 淡黄色针状结晶性粉末。熔点225-226℃。25℃水中溶解度为48mg/ml。碱性溶液中易破坏。

别名和识别编码

Chemical NamePyridine-2-Aldoxime Methiodide
CAS Number94-63-3
MDL NumberMFCD00011982
EC Number202-349-6
Synonym 2-Formyl-1-methylpyridinium iodide oxime 碘解磷啶 2-pyridinealdoximeiodomethylate Pralidoxime methiodide Pyridin-2-aldoxin 2-pyridinaldoximmethojodid 2-PYRIDINEALDOXIME METHIODIDE PYRIDINE-2-CARBOXALDOXIME METHIODIDE Pyridine-2-aldoxime methiodide LABOTEST-BB LT00455561 2-Hydroxyiminomethyl-1-methylpyridinium iodide PRALIDOXIME IODIDE Pyridine-2-aldoxime methyl iodide 2-PAM 碘化物 2-FORMYL-1-METHYLPYRIDINIUM IODIDE OXIME PAM 磷敌 2-Formyl-N-methylpyridinium oxime iodide Pralidoxime iodide 吡啶-2-甲醛肟碘甲烷盐 p-2-am 解磷定 1-methyl-2-hydroxyiminomethylpyridiniumiodide 碘解磷定 2-pamiodide 碘解磷 n-methylpyridinium-2-aldoximeiodide 2-Pyridine aldoxime iodomethylate 2-PAM iodide 1-methyl-2-aldoximinopyridiniumiodide 吡啶-2-乙醛肟甲碘化物 2-PAM
PubChem Substance ID135410029
Beilstein Registry Number4163555
Chemical Name Translation吡啶-2-乙醛肟甲碘化物
Merck Number13,7788
Wiswesser Line NotationT6KJ A1 B1UNQ &Q &I
InChIInChI=1S/C7H8N2O.HI/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H
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分类

  • {SNA} Building Blocks, C7, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
  • {SNA} Bioactive Small Molecules, Building Blocks, C7, Chemical Synthesis, Heterocyclic Building Blocks, PI-PY, Pyridines, 细胞生物学
  • {SNA} Bioactive Small Molecules, Building Blocks, C7, Cell Biology, Chemical Synthesis, Heterocyclic Building Blocks, P, Pyridines
  • {SNA} Bioactive Small Molecules, Building Blocks, C7, Chemical Synthesis, Heterocyclic Building Blocks, P,

安全信息

Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSUU4375000
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition Light Sensitive
Precautionary statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 132,50,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 305 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,202,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year: 5,21

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 129,31,1960

其他信息

  • 用途一:用于烷基磷酸酯类家药中毒的解毒剂。该品是胆碱酯酶再激活剂。
  • Alfa Aesar:Pyridine-2-aldoxime methiodide, 99%(94-63-3)
  • MOL 文件:94-63-3.mol
  • 上游原料:碘化钾 --> 2-甲基吡啶 --> 2-吡啶醛肟甲氯 --> 碘化钾饱和溶液
  • 方法一:由氯解磷定置换得到。将氯解磷定加等量水，加热溶解，搅拌下滴加碘化钾饱和溶液，析出结晶，过滤，甩干。再用蒸馏水重结晶，活性炭脱色得碘解磷定。
  • Sigma Aldrich:94-63-3(sigmaaldrich)

系列性分类

  1. C7 to C8 - Pyridines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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